Preliminary Results From a Prospective Study Using Limited Margin Radiotherapy in Pediatric and Young Adult Patients With High-Grade Nonrhabdomyosarcoma Soft-Tissue Sarcoma

Matthew J. Krasin, Andrew M. Davidoff, Xiaoping Xiong, Shengjie Wu, Chia H. Hua, Fariba Navid, Carlos Rodriguez-Galindo, Bhaskar N. Rao, Kelly A. Hoth, Michael D. Neel, Thomas E. Merchant, Larry E. Kun, Sheri L. Spunt

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Purpose: To demonstrate the safety and efficacy of limited margin radiotherapy in the local control of pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS). Methods and Materials: Pediatric patients with high-grade NRSTS requiring radiation were treated on an institutional review board approved prospective institutional study of conformal/intensity-modulated/interstitial brachytherapy using a 2-cm anatomically constrained margin. Results: A total of 32 patients (median age, 15.3 years; range, 2-22 years) received adjuvant (27 patients) or definitive (5 patients) irradiation. With a median follow-up of 32 months, the 3-year cumulative incidence of local failure was 3.7% for patients undergoing irradiation after surgical resection. Four patients experienced local failure; the mean dose to the volume of recurrence was ≥97% of the prescribed dose. Conclusions: Delivery of limited margin radiotherapy using external beam or brachytherapy provides a high rate of local tumor control without marginal failure. Further follow-up is required to determine whether normal tissue effects are minimized using this approach.

Original languageEnglish (US)
Pages (from-to)874-878
Number of pages5
JournalInternational Journal of Radiation Oncology Biology Physics
Volume76
Issue number3
DOIs
StatePublished - Mar 1 2010

Fingerprint

Sarcoma
Young Adult
radiation therapy
margins
grade
Radiotherapy
cancer
Prospective Studies
Pediatrics
Brachytherapy
dosage
irradiation
Research Ethics Committees
safety
delivery
interstitials
tumors
incidence
Radiation
Safety

Keywords

  • Conformal
  • IMRT
  • Margin
  • Radiation
  • Soft-tissue sarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Preliminary Results From a Prospective Study Using Limited Margin Radiotherapy in Pediatric and Young Adult Patients With High-Grade Nonrhabdomyosarcoma Soft-Tissue Sarcoma. / Krasin, Matthew J.; Davidoff, Andrew M.; Xiong, Xiaoping; Wu, Shengjie; Hua, Chia H.; Navid, Fariba; Rodriguez-Galindo, Carlos; Rao, Bhaskar N.; Hoth, Kelly A.; Neel, Michael D.; Merchant, Thomas E.; Kun, Larry E.; Spunt, Sheri L.

In: International Journal of Radiation Oncology Biology Physics, Vol. 76, No. 3, 01.03.2010, p. 874-878.

Research output: Contribution to journalArticle

Krasin, Matthew J. ; Davidoff, Andrew M. ; Xiong, Xiaoping ; Wu, Shengjie ; Hua, Chia H. ; Navid, Fariba ; Rodriguez-Galindo, Carlos ; Rao, Bhaskar N. ; Hoth, Kelly A. ; Neel, Michael D. ; Merchant, Thomas E. ; Kun, Larry E. ; Spunt, Sheri L. / Preliminary Results From a Prospective Study Using Limited Margin Radiotherapy in Pediatric and Young Adult Patients With High-Grade Nonrhabdomyosarcoma Soft-Tissue Sarcoma. In: International Journal of Radiation Oncology Biology Physics. 2010 ; Vol. 76, No. 3. pp. 874-878.
@article{2316326fb8ce43758ddac83ecab015ea,
title = "Preliminary Results From a Prospective Study Using Limited Margin Radiotherapy in Pediatric and Young Adult Patients With High-Grade Nonrhabdomyosarcoma Soft-Tissue Sarcoma",
abstract = "Purpose: To demonstrate the safety and efficacy of limited margin radiotherapy in the local control of pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS). Methods and Materials: Pediatric patients with high-grade NRSTS requiring radiation were treated on an institutional review board approved prospective institutional study of conformal/intensity-modulated/interstitial brachytherapy using a 2-cm anatomically constrained margin. Results: A total of 32 patients (median age, 15.3 years; range, 2-22 years) received adjuvant (27 patients) or definitive (5 patients) irradiation. With a median follow-up of 32 months, the 3-year cumulative incidence of local failure was 3.7{\%} for patients undergoing irradiation after surgical resection. Four patients experienced local failure; the mean dose to the volume of recurrence was ≥97{\%} of the prescribed dose. Conclusions: Delivery of limited margin radiotherapy using external beam or brachytherapy provides a high rate of local tumor control without marginal failure. Further follow-up is required to determine whether normal tissue effects are minimized using this approach.",
keywords = "Conformal, IMRT, Margin, Radiation, Soft-tissue sarcoma",
author = "Krasin, {Matthew J.} and Davidoff, {Andrew M.} and Xiaoping Xiong and Shengjie Wu and Hua, {Chia H.} and Fariba Navid and Carlos Rodriguez-Galindo and Rao, {Bhaskar N.} and Hoth, {Kelly A.} and Neel, {Michael D.} and Merchant, {Thomas E.} and Kun, {Larry E.} and Spunt, {Sheri L.}",
year = "2010",
month = "3",
day = "1",
doi = "10.1016/j.ijrobp.2009.02.074",
language = "English (US)",
volume = "76",
pages = "874--878",
journal = "International Journal of Radiation Oncology Biology Physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Preliminary Results From a Prospective Study Using Limited Margin Radiotherapy in Pediatric and Young Adult Patients With High-Grade Nonrhabdomyosarcoma Soft-Tissue Sarcoma

AU - Krasin, Matthew J.

AU - Davidoff, Andrew M.

AU - Xiong, Xiaoping

AU - Wu, Shengjie

AU - Hua, Chia H.

AU - Navid, Fariba

AU - Rodriguez-Galindo, Carlos

AU - Rao, Bhaskar N.

AU - Hoth, Kelly A.

AU - Neel, Michael D.

AU - Merchant, Thomas E.

AU - Kun, Larry E.

AU - Spunt, Sheri L.

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Purpose: To demonstrate the safety and efficacy of limited margin radiotherapy in the local control of pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS). Methods and Materials: Pediatric patients with high-grade NRSTS requiring radiation were treated on an institutional review board approved prospective institutional study of conformal/intensity-modulated/interstitial brachytherapy using a 2-cm anatomically constrained margin. Results: A total of 32 patients (median age, 15.3 years; range, 2-22 years) received adjuvant (27 patients) or definitive (5 patients) irradiation. With a median follow-up of 32 months, the 3-year cumulative incidence of local failure was 3.7% for patients undergoing irradiation after surgical resection. Four patients experienced local failure; the mean dose to the volume of recurrence was ≥97% of the prescribed dose. Conclusions: Delivery of limited margin radiotherapy using external beam or brachytherapy provides a high rate of local tumor control without marginal failure. Further follow-up is required to determine whether normal tissue effects are minimized using this approach.

AB - Purpose: To demonstrate the safety and efficacy of limited margin radiotherapy in the local control of pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS). Methods and Materials: Pediatric patients with high-grade NRSTS requiring radiation were treated on an institutional review board approved prospective institutional study of conformal/intensity-modulated/interstitial brachytherapy using a 2-cm anatomically constrained margin. Results: A total of 32 patients (median age, 15.3 years; range, 2-22 years) received adjuvant (27 patients) or definitive (5 patients) irradiation. With a median follow-up of 32 months, the 3-year cumulative incidence of local failure was 3.7% for patients undergoing irradiation after surgical resection. Four patients experienced local failure; the mean dose to the volume of recurrence was ≥97% of the prescribed dose. Conclusions: Delivery of limited margin radiotherapy using external beam or brachytherapy provides a high rate of local tumor control without marginal failure. Further follow-up is required to determine whether normal tissue effects are minimized using this approach.

KW - Conformal

KW - IMRT

KW - Margin

KW - Radiation

KW - Soft-tissue sarcoma

UR - http://www.scopus.com/inward/record.url?scp=76049084599&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76049084599&partnerID=8YFLogxK

U2 - 10.1016/j.ijrobp.2009.02.074

DO - 10.1016/j.ijrobp.2009.02.074

M3 - Article

VL - 76

SP - 874

EP - 878

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

SN - 0360-3016

IS - 3

ER -