Preoperative mean platelet volume and platelet distribution associated with thyroid cancer

Y. J. Yu, N. Li, Z. Y. Yun, Y. Niu, J. J. Xu, Z. P. Liu, T. Liu, R. T. Wang, K. J. Yu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Thyroid cancer is the most frequent cancer of the endocrine glands and the fifth most frequent cancer in women. Activated platelets play a crucial role in thrombosis, inflammation, and cancer. Mean platelet volume (MPV) and platelet distribution width (PDW) are early index of platelet activation. The purpose of this study is to investigate platelet indices levels in thyroid cancer. The study enrolled 280 patients with thyroid cancer and 280 control subjects. Patients’ characteristics and hematologic tests data were collected at the time of diagnosis. Correlations between platelet indices and clinical characteristics were analyzed. The odds ratios (ORs) and 95% confidence intervals (CIs) for thyroid cancer were calculated using multivariate logistic regression analyses across MPV and PDW quartiles. The patients with thyroid cancer had lower MPV and higher PDW compared with control subjects. MPV was correlated with tumor-nodus-metastases (TNM) stage and lymph node metastasis. Moreover, after adjusting for other risk factors, the prevalence risk of thyroid cancer for the lowest quartile of MPV was 7.242 (4.069-12.887) (P < 0.001) and for the highest quartile of PDW was 6.065 (3.321-11.076) (P < 0.001), respectively. The study showed that the patients with thyroid cancer have lower MPV and higher PDW compared to control subjects. Moreover, MPV and PDW were independently associated with the presence of thyroid cancer. Further studies are needed to evaluate the utility of MPV and PDW as novel diagnostic screening tools for thyroid cancer.

Original languageEnglish (US)
Pages (from-to)594-598
Number of pages5
JournalNeoplasma
Volume64
Issue number4
DOIs
StatePublished - 2017

Fingerprint

Mean Platelet Volume
Thyroid Neoplasms
Blood Platelets
Endocrine Gland Neoplasms
Neoplasm Metastasis
Neoplasms
Platelet Activation
Hematologic Tests
Thrombosis
Logistic Models
Lymph Nodes
Odds Ratio
Regression Analysis

Keywords

  • Mean platelet volume
  • Platelet activation
  • Platelet distribution width
  • Thyroid cancer

ASJC Scopus subject areas

  • Cancer Research

Cite this

Preoperative mean platelet volume and platelet distribution associated with thyroid cancer. / Yu, Y. J.; Li, N.; Yun, Z. Y.; Niu, Y.; Xu, J. J.; Liu, Z. P.; Liu, T.; Wang, R. T.; Yu, K. J.

In: Neoplasma, Vol. 64, No. 4, 2017, p. 594-598.

Research output: Contribution to journalArticle

Yu, YJ, Li, N, Yun, ZY, Niu, Y, Xu, JJ, Liu, ZP, Liu, T, Wang, RT & Yu, KJ 2017, 'Preoperative mean platelet volume and platelet distribution associated with thyroid cancer', Neoplasma, vol. 64, no. 4, pp. 594-598. https://doi.org/10.4149/neo_2017_414
Yu, Y. J. ; Li, N. ; Yun, Z. Y. ; Niu, Y. ; Xu, J. J. ; Liu, Z. P. ; Liu, T. ; Wang, R. T. ; Yu, K. J. / Preoperative mean platelet volume and platelet distribution associated with thyroid cancer. In: Neoplasma. 2017 ; Vol. 64, No. 4. pp. 594-598.
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