Preparation and biodistribution of novel 99mTc(CO) 3-CNR complexes for myocardial imaging

Guiyang Hao, Jianying Zang, Boli Liu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We evaluated lipophilicity and biodistribution of a series of 99mTc(CO)3-ether isonitrile complexes to determine whether different lipophilicity and structure of isonitrile ligands would improve the imaging properties of the radiopharmaceutical for the heart. Novel 99mTc(CO)3-MIBI analogs were prepared and analyzed by radio-HPLC, and their lipophilicity was determined. These new complexes could be bi- or tri-substituted in specified pH conditions like 99mTc(CO) 3-MIBI. These new complexes exhibited low liver, lungs and blood uptake compared with [99mTc(CO)3(MIBI)3] + though their heart uptake was not so high. Among these complexes, [99mTc(CO)3(EPI)2(OH2)]+ showed higher target to non-target ratios at 5 and 30 min post-injection than that of [99mTc(CO)3(MIBI)3]+.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume50
Issue number1
DOIs
StatePublished - Jan 2007

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Carbon Monoxide
Imaging techniques
Radiopharmaceuticals
Radio
Liver
Ether
Blood
High Pressure Liquid Chromatography
Ligands
Lung
Injections

Keywords

  • Isonitrile
  • Myocardial imaging
  • Tc-99m
  • Tricarbonyl

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Organic Chemistry
  • Clinical Biochemistry
  • Molecular Medicine
  • Pharmacology

Cite this

Preparation and biodistribution of novel 99mTc(CO) 3-CNR complexes for myocardial imaging. / Hao, Guiyang; Zang, Jianying; Liu, Boli.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 50, No. 1, 01.2007, p. 13-18.

Research output: Contribution to journalArticle

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