Preparation and characterization of atenolol-loaded cellulose acetate butyrate-poly(vinyl pyrrolidone) blend microspheres

In vitro release studies

V. Ramesh Babu, K. Mallikarjuna Reddy, M. Sairam, M. C S Subha, N. N. Mallikarjuna, P. V. Kulkarni, T. M. Aminabhavi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Cellulose acetate butyrate-poly(vinyl pyrrolidone) (CAB-PVP) blend microspheres were prepared using the solvent evaporation technique using poly(vinyl alcohol) as an emulsifying agent. Atenolol (ATNL), an antihypertensive drug, was successfully loaded into these microspheres. Effect of experimental variables such as CAB/PVP ratio on ATNL encapsulation efficiency, release rate, size and morphology of the microspheres has been investigated. ATNL-loaded microspheres were analyzed using differential scanning calorimetry to investigate the crystalline nature of ATNL after encapsulation. DSC results indicated a non-uniform dispersion of ATNL in CAB-PVP blend matrix. Scanning electron micrographs indicated the formation of spherical microspheres. Mean particle size of the microspheres, as measured by the laser light scattering technique, ranged between 100 and 120 μm. An encapsulation of about 80% of ATNL was achieved. In vitro dissolution experiments performed in pH 7.4 buffer medium indicated the controlled release of atenolol from the blend microspheres up to 10 h.

Original languageEnglish (US)
Pages (from-to)155-165
Number of pages11
JournalDesigned Monomers and Polymers
Volume10
Issue number2
DOIs
StatePublished - 2007

Fingerprint

Pyrrolidinones
Atenolol
Microspheres
Cellulose
Encapsulation
cellulose acetate-butyrate
Light scattering
Antihypertensive Agents
Differential scanning calorimetry
Buffers
Dissolution
Evaporation
Alcohols
Particle size
Crystalline materials
Scanning
Electrons
Lasers

Keywords

  • Atenolol
  • Cellulose acetate butyrate
  • Controlled release
  • Microspheres
  • Poly(vinyl pyrrolidone)

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry

Cite this

Preparation and characterization of atenolol-loaded cellulose acetate butyrate-poly(vinyl pyrrolidone) blend microspheres : In vitro release studies. / Ramesh Babu, V.; Mallikarjuna Reddy, K.; Sairam, M.; Subha, M. C S; Mallikarjuna, N. N.; Kulkarni, P. V.; Aminabhavi, T. M.

In: Designed Monomers and Polymers, Vol. 10, No. 2, 2007, p. 155-165.

Research output: Contribution to journalArticle

Ramesh Babu, V. ; Mallikarjuna Reddy, K. ; Sairam, M. ; Subha, M. C S ; Mallikarjuna, N. N. ; Kulkarni, P. V. ; Aminabhavi, T. M. / Preparation and characterization of atenolol-loaded cellulose acetate butyrate-poly(vinyl pyrrolidone) blend microspheres : In vitro release studies. In: Designed Monomers and Polymers. 2007 ; Vol. 10, No. 2. pp. 155-165.
@article{0d261021a24f4cca972614c7229a9539,
title = "Preparation and characterization of atenolol-loaded cellulose acetate butyrate-poly(vinyl pyrrolidone) blend microspheres: In vitro release studies",
abstract = "Cellulose acetate butyrate-poly(vinyl pyrrolidone) (CAB-PVP) blend microspheres were prepared using the solvent evaporation technique using poly(vinyl alcohol) as an emulsifying agent. Atenolol (ATNL), an antihypertensive drug, was successfully loaded into these microspheres. Effect of experimental variables such as CAB/PVP ratio on ATNL encapsulation efficiency, release rate, size and morphology of the microspheres has been investigated. ATNL-loaded microspheres were analyzed using differential scanning calorimetry to investigate the crystalline nature of ATNL after encapsulation. DSC results indicated a non-uniform dispersion of ATNL in CAB-PVP blend matrix. Scanning electron micrographs indicated the formation of spherical microspheres. Mean particle size of the microspheres, as measured by the laser light scattering technique, ranged between 100 and 120 μm. An encapsulation of about 80{\%} of ATNL was achieved. In vitro dissolution experiments performed in pH 7.4 buffer medium indicated the controlled release of atenolol from the blend microspheres up to 10 h.",
keywords = "Atenolol, Cellulose acetate butyrate, Controlled release, Microspheres, Poly(vinyl pyrrolidone)",
author = "{Ramesh Babu}, V. and {Mallikarjuna Reddy}, K. and M. Sairam and Subha, {M. C S} and Mallikarjuna, {N. N.} and Kulkarni, {P. V.} and Aminabhavi, {T. M.}",
year = "2007",
doi = "10.1163/156855507780378276",
language = "English (US)",
volume = "10",
pages = "155--165",
journal = "Designed Monomers and Polymers",
issn = "1385-772X",
publisher = "Taylor and Francis Ltd.",
number = "2",

}

TY - JOUR

T1 - Preparation and characterization of atenolol-loaded cellulose acetate butyrate-poly(vinyl pyrrolidone) blend microspheres

T2 - In vitro release studies

AU - Ramesh Babu, V.

AU - Mallikarjuna Reddy, K.

AU - Sairam, M.

AU - Subha, M. C S

AU - Mallikarjuna, N. N.

AU - Kulkarni, P. V.

AU - Aminabhavi, T. M.

PY - 2007

Y1 - 2007

N2 - Cellulose acetate butyrate-poly(vinyl pyrrolidone) (CAB-PVP) blend microspheres were prepared using the solvent evaporation technique using poly(vinyl alcohol) as an emulsifying agent. Atenolol (ATNL), an antihypertensive drug, was successfully loaded into these microspheres. Effect of experimental variables such as CAB/PVP ratio on ATNL encapsulation efficiency, release rate, size and morphology of the microspheres has been investigated. ATNL-loaded microspheres were analyzed using differential scanning calorimetry to investigate the crystalline nature of ATNL after encapsulation. DSC results indicated a non-uniform dispersion of ATNL in CAB-PVP blend matrix. Scanning electron micrographs indicated the formation of spherical microspheres. Mean particle size of the microspheres, as measured by the laser light scattering technique, ranged between 100 and 120 μm. An encapsulation of about 80% of ATNL was achieved. In vitro dissolution experiments performed in pH 7.4 buffer medium indicated the controlled release of atenolol from the blend microspheres up to 10 h.

AB - Cellulose acetate butyrate-poly(vinyl pyrrolidone) (CAB-PVP) blend microspheres were prepared using the solvent evaporation technique using poly(vinyl alcohol) as an emulsifying agent. Atenolol (ATNL), an antihypertensive drug, was successfully loaded into these microspheres. Effect of experimental variables such as CAB/PVP ratio on ATNL encapsulation efficiency, release rate, size and morphology of the microspheres has been investigated. ATNL-loaded microspheres were analyzed using differential scanning calorimetry to investigate the crystalline nature of ATNL after encapsulation. DSC results indicated a non-uniform dispersion of ATNL in CAB-PVP blend matrix. Scanning electron micrographs indicated the formation of spherical microspheres. Mean particle size of the microspheres, as measured by the laser light scattering technique, ranged between 100 and 120 μm. An encapsulation of about 80% of ATNL was achieved. In vitro dissolution experiments performed in pH 7.4 buffer medium indicated the controlled release of atenolol from the blend microspheres up to 10 h.

KW - Atenolol

KW - Cellulose acetate butyrate

KW - Controlled release

KW - Microspheres

KW - Poly(vinyl pyrrolidone)

UR - http://www.scopus.com/inward/record.url?scp=34249720082&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249720082&partnerID=8YFLogxK

U2 - 10.1163/156855507780378276

DO - 10.1163/156855507780378276

M3 - Article

VL - 10

SP - 155

EP - 165

JO - Designed Monomers and Polymers

JF - Designed Monomers and Polymers

SN - 1385-772X

IS - 2

ER -