TY - JOUR
T1 - Prescribing
T2 - Reducing costs through in-class therapeutic interchange
AU - Stenner, Shane P.
AU - Chakravarthy, Rohini
AU - Johnson, Kevin B.
AU - Miller, William L.
AU - Olson, Julie
AU - Wickizer, Marleen
AU - Johnson, Nate N.
AU - Ohmer, Rick
AU - Uskavitch, David R.
AU - Bernard, Gordon R.
AU - Neal, Erin B.
AU - Lehmann, Christoph U.
N1 - Publisher Copyright:
© Schattauer 2016.
PY - 2016/12/14
Y1 - 2016/12/14
N2 - Introduction: Spending on pharmaceuticals in the US reached $373.9 billion in 2014. Therapeutic interchange offers potential medication cost savings by replacing a prescribed drug for an equally efficacious therapeutic alternative. Methods: Hard-stop therapeutic interchange recommendation alerts were developed for four medication classes (HMG-CoA reductase inhibitors, serotonin receptor agonists, intranasal steroid sprays, and proton-pump inhibitors) in an electronic prescription-writing tool for outpatient prescriptions. Using prescription data from January 2012 to June 2015, the Compliance Ratio (CR) was calculated by dividing the number of prescriptions with recommended therapeutic interchange medications by the number of prescriptions with non-recommended medications to measure effectiveness. To explore potential cost savings, prescription data and medication costs were analyzed for the 45,000 Vanderbilt Employee Health Plan members. Results: For all medication classes, significant improvements were demonstrated-the CR improved (proton-pump inhibitors 2.8 to 5.32, nasal steroids 2.44 to 8.16, statins 2.06 to 5.51, and serotonin receptor agonists 0.8 to 1.52). Quarterly savings through the four therapeutic interchange interventions combined exceeded $200,000 with an estimated annual savings for the health plan of $800,000, or more than $17 per member. Conclusion: A therapeutic interchange clinical decision support tool at the point of prescribing resulted in increased compliance with recommendations for outpatient prescriptions while producing substantial cost savings to the Vanderbilt Employee Health Plan-$17.77 per member per year. Therapeutic interchange rules require rational targeting, appropriate governance, and vigilant content updates.
AB - Introduction: Spending on pharmaceuticals in the US reached $373.9 billion in 2014. Therapeutic interchange offers potential medication cost savings by replacing a prescribed drug for an equally efficacious therapeutic alternative. Methods: Hard-stop therapeutic interchange recommendation alerts were developed for four medication classes (HMG-CoA reductase inhibitors, serotonin receptor agonists, intranasal steroid sprays, and proton-pump inhibitors) in an electronic prescription-writing tool for outpatient prescriptions. Using prescription data from January 2012 to June 2015, the Compliance Ratio (CR) was calculated by dividing the number of prescriptions with recommended therapeutic interchange medications by the number of prescriptions with non-recommended medications to measure effectiveness. To explore potential cost savings, prescription data and medication costs were analyzed for the 45,000 Vanderbilt Employee Health Plan members. Results: For all medication classes, significant improvements were demonstrated-the CR improved (proton-pump inhibitors 2.8 to 5.32, nasal steroids 2.44 to 8.16, statins 2.06 to 5.51, and serotonin receptor agonists 0.8 to 1.52). Quarterly savings through the four therapeutic interchange interventions combined exceeded $200,000 with an estimated annual savings for the health plan of $800,000, or more than $17 per member. Conclusion: A therapeutic interchange clinical decision support tool at the point of prescribing resulted in increased compliance with recommendations for outpatient prescriptions while producing substantial cost savings to the Vanderbilt Employee Health Plan-$17.77 per member per year. Therapeutic interchange rules require rational targeting, appropriate governance, and vigilant content updates.
KW - Cost savings
KW - Electronic health record
KW - Electronic prescribing
KW - Therapeutic interchange
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U2 - 10.4338/ACI-2016-09-RA-0160
DO - 10.4338/ACI-2016-09-RA-0160
M3 - Article
C2 - 27966005
AN - SCOPUS:85007343048
SN - 1869-0327
VL - 7
SP - 1168
EP - 1181
JO - Applied Clinical Informatics
JF - Applied Clinical Informatics
IS - 4
ER -