Prevalence and determinants of troponin T elevation in the general population

Thomas W. Wallace, Shuaib M Abdullah, Mark H Drazner, Sandeep R Das, Amit Khera, Darren K McGuire, Frank Wians, Marc S. Sabatine, David A. Morrow, James A de Lemos

Research output: Contribution to journalArticle

337 Scopus citations

Abstract

Background - The prevalence and determinants of cardiac troponin T (cTnT) elevation in the general population are unknown, and the significance of minimally increased cTnT remains controversial. Our objective was to determine the prevalence and determinants of cTnT elevation in a large, representative sample of the general population. Methods and Results - cTnT was measured from stored plasma samples in 3557 subjects of the Dallas Heart Study, a population-based sample. cTnT elevation (≥0.01 μg/L) was correlated with clinical variables and cardiac MRI findings. The sample weight-adjusted prevalence of cTnT elevation in the general population was 0.7%. In univariable analyses, cTnT elevation was associated with older age, black race, male sex, coronary artery calcium by electron beam CT, a composite marker of congestive heart failure (CHF), left ventricular hypertrophy (LVH), diabetes mellitus (DM), and chronic kidney disease (CKD) (P<0.001 for each). Subjects with minimally increased (0.01 to 0.029 μg/L) and increased (≥0.03 μg/L) cTnT had a similar prevalence of these characteristics. In multivariable logistic regression analysis, LVH, CHF, DM, and CKD were independently associated with cTnT elevation. Conclusions - In the general population, cTnT elevation is rare in subjects without CHF, LVH, CKD, or DM, suggesting that the upper limit of normal for the immunoassay should be <0.01 μg/L. Even minimally increased cTnT may represent subclinical cardiac injury and have important clinical implications, a hypothesis that should be tested in longitudinal outcome studies.

Original languageEnglish (US)
Pages (from-to)1958-1965
Number of pages8
JournalCirculation
Volume113
Issue number16
DOIs
StatePublished - Apr 1 2006

Keywords

  • Diabetes mellitus
  • Hypertrophy
  • Kidney
  • Population
  • Troponin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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