Prevalence of nosocomial infections in neonatal intensive care unit patients: Results from the first national point-prevalence survey

Annette H. Sohn, Denise O. Garrett, Ronda L. Sinkowitz-Cochran, Lisa A. Grohskopf, Gail L. Levine, Beth H. Stover, Jane D. Siegel, William R. Jarvis

Research output: Contribution to journalArticle

296 Scopus citations

Abstract

Objectives: Patients admitted to neonatal intensive care units (NICUs) are at high risk of nosocomial infection. We conducted a national multicenter assessment of nosocomial infections in NICUs to determine the prevalence of infections, describe associated risk factors, and help focus prevention efforts. Study design: We conducted a point prevalence survey of nosocomial infections in 29 Pediatric Prevention Network NICUs. Patients present on the survey date were included. Data were collected on underlying diagnoses, therapeutic interventions/treatments, infections, and outcomes. Results: Of the 827 patients surveyed, 94 (11.4%) had 116 NICU-acquired infections: bloodstream (52.6%), lower respiratory tract (12.9%), ear-nose-throat (8.6%), or urinary tract infections (8.6%). Infants with infections were of significantly lower birth weight (median 1006 g [range 441 to 4460 g] vs 1589 g [range 326 to 5480 g]; P < .001) and had longer median durations of stay than those without infections (88 days [range 8 to 279 days] vs 32 days [range 1 to 483 days]; P < .001). Most common pathogens were coagulase-negative staphylococci and enterococci. Patients with central intravascular catheters (relative risk = 3.81, CI 2.32-6.25; P < .001) or receiving total parenteral nutrition (relative risk = 5.72, CI 3.45-9.49; P < .001) were at greater risk of bloodstream infection. Conclusions: This study documents the high prevalence of nosocomial infections in patients in NICUs and the urgent need for more effective prevention interventions.

Original languageEnglish (US)
Pages (from-to)821-827
Number of pages7
JournalJournal of Pediatrics
Volume139
Issue number6
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Sohn, A. H., Garrett, D. O., Sinkowitz-Cochran, R. L., Grohskopf, L. A., Levine, G. L., Stover, B. H., Siegel, J. D., & Jarvis, W. R. (2001). Prevalence of nosocomial infections in neonatal intensive care unit patients: Results from the first national point-prevalence survey. Journal of Pediatrics, 139(6), 821-827. https://doi.org/10.1067/mpd.2001.119442