TY - JOUR
T1 - Prevalence of nosocomial infections in neonatal intensive care unit patients
T2 - Results from the first national point-prevalence survey
AU - Sohn, Annette H.
AU - Garrett, Denise O.
AU - Sinkowitz-Cochran, Ronda L.
AU - Grohskopf, Lisa A.
AU - Levine, Gail L.
AU - Stover, Beth H.
AU - Siegel, Jane D.
AU - Jarvis, William R.
N1 - Funding Information:
From the Division of Healthcare Quality Promotion (formerly Hospital Infections Program), National Center for Infectious Diseases, Centers for Disease Control and Prevention; Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, CDC, Public Health Service, United States Department of Health and Human Services, Atlanta, Georgia; the National Association of Children’s Hospitals and Related Institutions (NACHRI), Alexandria, Virginia; Kosair Children’s Hospital – Norton Healthcare Inc, Louisville, Kentucky; and University of Texas Southwestern Medical Center, Dallas, Texas.
PY - 2001
Y1 - 2001
N2 - Objectives: Patients admitted to neonatal intensive care units (NICUs) are at high risk of nosocomial infection. We conducted a national multicenter assessment of nosocomial infections in NICUs to determine the prevalence of infections, describe associated risk factors, and help focus prevention efforts. Study design: We conducted a point prevalence survey of nosocomial infections in 29 Pediatric Prevention Network NICUs. Patients present on the survey date were included. Data were collected on underlying diagnoses, therapeutic interventions/treatments, infections, and outcomes. Results: Of the 827 patients surveyed, 94 (11.4%) had 116 NICU-acquired infections: bloodstream (52.6%), lower respiratory tract (12.9%), ear-nose-throat (8.6%), or urinary tract infections (8.6%). Infants with infections were of significantly lower birth weight (median 1006 g [range 441 to 4460 g] vs 1589 g [range 326 to 5480 g]; P < .001) and had longer median durations of stay than those without infections (88 days [range 8 to 279 days] vs 32 days [range 1 to 483 days]; P < .001). Most common pathogens were coagulase-negative staphylococci and enterococci. Patients with central intravascular catheters (relative risk = 3.81, CI 2.32-6.25; P < .001) or receiving total parenteral nutrition (relative risk = 5.72, CI 3.45-9.49; P < .001) were at greater risk of bloodstream infection. Conclusions: This study documents the high prevalence of nosocomial infections in patients in NICUs and the urgent need for more effective prevention interventions.
AB - Objectives: Patients admitted to neonatal intensive care units (NICUs) are at high risk of nosocomial infection. We conducted a national multicenter assessment of nosocomial infections in NICUs to determine the prevalence of infections, describe associated risk factors, and help focus prevention efforts. Study design: We conducted a point prevalence survey of nosocomial infections in 29 Pediatric Prevention Network NICUs. Patients present on the survey date were included. Data were collected on underlying diagnoses, therapeutic interventions/treatments, infections, and outcomes. Results: Of the 827 patients surveyed, 94 (11.4%) had 116 NICU-acquired infections: bloodstream (52.6%), lower respiratory tract (12.9%), ear-nose-throat (8.6%), or urinary tract infections (8.6%). Infants with infections were of significantly lower birth weight (median 1006 g [range 441 to 4460 g] vs 1589 g [range 326 to 5480 g]; P < .001) and had longer median durations of stay than those without infections (88 days [range 8 to 279 days] vs 32 days [range 1 to 483 days]; P < .001). Most common pathogens were coagulase-negative staphylococci and enterococci. Patients with central intravascular catheters (relative risk = 3.81, CI 2.32-6.25; P < .001) or receiving total parenteral nutrition (relative risk = 5.72, CI 3.45-9.49; P < .001) were at greater risk of bloodstream infection. Conclusions: This study documents the high prevalence of nosocomial infections in patients in NICUs and the urgent need for more effective prevention interventions.
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U2 - 10.1067/mpd.2001.119442
DO - 10.1067/mpd.2001.119442
M3 - Article
C2 - 11743507
AN - SCOPUS:0035668353
SN - 0022-3476
VL - 139
SP - 821
EP - 827
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 6
ER -