Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism

Nathan M. Krah, Shuba M. Narayanan, Deanne E. Yugawa, Julie A. Straley, Christopher V.E. Wright, Raymond J MacDonald, L. Charles Murtaugh

Research output: Contribution to journalArticle

Abstract

Pancreatic cancer arises from mutations in exocrine acinar cells. Krah et al. demonstrate that preserving acinar cell identity protects these cells from oncogenic Kras-induced tumorigenesis. Furthermore, re-expressing the acinar differentiation gene Ptf1a in existing precancerous lesions in vivo, or human pancreatic cancer cells in vitro, induces quiescence and re-differentiation.

Original languageEnglish (US)
Pages (from-to)744-754.e4
JournalDevelopmental Cell
Volume50
Issue number6
DOIs
StatePublished - Sep 23 2019

Fingerprint

Acinar Cells
Pancreatic Neoplasms
Carcinogenesis
Genes
Cells
Mutation
In Vitro Techniques

Keywords

  • acinar cell
  • differentiation
  • Kras
  • pancreas
  • pancreatic cancer
  • Ptf1a

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

Cite this

Krah, N. M., Narayanan, S. M., Yugawa, D. E., Straley, J. A., Wright, C. V. E., MacDonald, R. J., & Murtaugh, L. C. (2019). Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism. Developmental Cell, 50(6), 744-754.e4. https://doi.org/10.1016/j.devcel.2019.07.012

Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism. / Krah, Nathan M.; Narayanan, Shuba M.; Yugawa, Deanne E.; Straley, Julie A.; Wright, Christopher V.E.; MacDonald, Raymond J; Murtaugh, L. Charles.

In: Developmental Cell, Vol. 50, No. 6, 23.09.2019, p. 744-754.e4.

Research output: Contribution to journalArticle

Krah, NM, Narayanan, SM, Yugawa, DE, Straley, JA, Wright, CVE, MacDonald, RJ & Murtaugh, LC 2019, 'Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism', Developmental Cell, vol. 50, no. 6, pp. 744-754.e4. https://doi.org/10.1016/j.devcel.2019.07.012
Krah, Nathan M. ; Narayanan, Shuba M. ; Yugawa, Deanne E. ; Straley, Julie A. ; Wright, Christopher V.E. ; MacDonald, Raymond J ; Murtaugh, L. Charles. / Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism. In: Developmental Cell. 2019 ; Vol. 50, No. 6. pp. 744-754.e4.
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