Primary adenocarcinoma of the urinary bladder: Value of cell cycle biomarkers

Payal Kapur, Yair Lotan, Ellen S King, Wareef Kabbani, Anirban P. Mitra, Ahmed Mosbah, Hassan Abol-Enein, Mohamed Ghoneim, Ramy F. Youssef

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17 Scopus citations

Abstract

Primary adenocarcinomas of the urinary bladder are uncommon, and the molecular pathways are currently not well defined. In this study, we assessed the association between biologic markers and clinicopathologic characteristics in a cohort of 21 patients with primary urinary bladder adenocarcinoma. Immunohistochemical staining for cell cycle-specific markers, including p53, p21, p27, Ki-67, and cyclin E, were performed on sections of a tissue microarray construct. The tumors were high grade in 12 (57%) and pT2 or higher in 18 (86%); lymph nodes were involved in 6 cases (29%); and there was pathologic evidence of schistosomiasis in 14 (67%). The best prognostic combination of markers was combined alterations in p27 and Ki-67 and was associated with stage (P = .012), grade (P = .005), DNA ploidy (P = .005), and lymph node involvement (P = .04). Stage, lymph node involvement, combined alterations of p27 and Ki-67, and combined alterations of all 5 biomarkers were associated with increased probability of disease recurrence and cancer-specific mortality (P < .05).

Original languageEnglish (US)
Pages (from-to)822-830
Number of pages9
JournalAmerican journal of clinical pathology
Volume135
Issue number6
DOIs
StatePublished - Jun 1 2011

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Keywords

  • Adenocarcinoma of the urinary bladder
  • Bladder cancer markers
  • Immunohistochemistry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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