Primary germ cell tumours of the mediastinum.

K. V. Albuquerque, R. C. Mistry, R. K. Deshpande, P. B. Desai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Twenty nine cases of primary mediastinal germ cell tumours (MGCT) were seen at the Tata Memorial Hospital over a 16--year period (1974-1989). There were 5 benign MGCT occurring predominantly in females (80%), with these patients having an excellent result after surgery with all patients disease free at an median follow-up of 27 months. Malignant MGCT occurred only in males and demonstrated wide variation in response to treatment depending upon whether the tumour was seminomatous or non-seminomatous. There were 11 Seminomas, 5 Embryonal carcinomas, 5 Endodermal sinus tumours and 3 Teratocarcinomas. The diagnosis was established by surgical exploration or by biopsy of a lymph node or chest wall nodule in 20 patients. Four patients had needle biopsy. Seminomatous MGCT received radiotherapy as their main treatment modality and did well with 75% of the patients alive without disease at an average follow up of 33 months. The non-seminomatous MGCT could be divided into two groups. The mean survival for patients receiving cisplatinum based chemotherapy was 14 months as compared to the group not receiving such therapy where the survival was only 5.3 months. However, because of the advanced disease at presentation even in the group receiving cisplatinum chemotherapy, a long term complete response rate of only 20% could be achieved.

Original languageEnglish (US)
Pages (from-to)250-256
Number of pages7
JournalIndian Journal of Cancer
Volume31
Issue number4
StatePublished - Dec 1994

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Germ Cell and Embryonal Neoplasms
Mediastinum
Embryonal Carcinoma
Endodermal Sinus Tumor
Teratocarcinoma
Drug Therapy
Seminoma
Survival
Needle Biopsy
Thoracic Wall
Radiotherapy
Therapeutics
Lymph Nodes
Biopsy
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Medicine(all)
  • Oncology

Cite this

Albuquerque, K. V., Mistry, R. C., Deshpande, R. K., & Desai, P. B. (1994). Primary germ cell tumours of the mediastinum. Indian Journal of Cancer, 31(4), 250-256.

Primary germ cell tumours of the mediastinum. / Albuquerque, K. V.; Mistry, R. C.; Deshpande, R. K.; Desai, P. B.

In: Indian Journal of Cancer, Vol. 31, No. 4, 12.1994, p. 250-256.

Research output: Contribution to journalArticle

Albuquerque, KV, Mistry, RC, Deshpande, RK & Desai, PB 1994, 'Primary germ cell tumours of the mediastinum.', Indian Journal of Cancer, vol. 31, no. 4, pp. 250-256.
Albuquerque KV, Mistry RC, Deshpande RK, Desai PB. Primary germ cell tumours of the mediastinum. Indian Journal of Cancer. 1994 Dec;31(4):250-256.
Albuquerque, K. V. ; Mistry, R. C. ; Deshpande, R. K. ; Desai, P. B. / Primary germ cell tumours of the mediastinum. In: Indian Journal of Cancer. 1994 ; Vol. 31, No. 4. pp. 250-256.
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