Prognostic role of decreased E-cadherin expression in patients with upper tract urothelial carcinoma: a multi-institutional study

Ricardo L. Favaretto, Atessa Bahadori, Romain Mathieu, Andrea Haitel, Bernhard Grubmüller, Vitaly Margulis, Jose A. Karam, Morgan Rouprêt, Christian Seitz, Pierre I. Karakiewicz, Isabela W. Cunha, Stenio C. Zequi, Christopher G. Wood, Alon Z. Weizer, Jay D. Raman, Mesut Remzi, Nathalie Rioux-Leclercq, Solene Jacquet-Kammerer, Karim Bensalah, Yair LotanAlexander Bachmann, Michael Rink, Alberto Briganti, Shahrokh F. Shariat

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Purpose: To assess the role of E-cadherin as prognostic biomarker in upper tract urothelial carcinoma (UTUC) in a large multi-institutional cohort of patients. Methods: Immunohistochemistry technique was used to evaluate E-cadherin expression in 678 patients with unilateral, sporadic UTUC treated with RNU. E-cadherin expression was considered decreased if 10 % or more cells had decreased expression (

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalWorld Journal of Urology
DOIs
StateAccepted/In press - Apr 29 2016

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Keywords

  • Carcinoma
  • E-cadherin
  • Prediction
  • Prognosis
  • Recurrence
  • Survival
  • Urothelium

ASJC Scopus subject areas

  • Urology

Cite this

Favaretto, R. L., Bahadori, A., Mathieu, R., Haitel, A., Grubmüller, B., Margulis, V., Karam, J. A., Rouprêt, M., Seitz, C., Karakiewicz, P. I., Cunha, I. W., Zequi, S. C., Wood, C. G., Weizer, A. Z., Raman, J. D., Remzi, M., Rioux-Leclercq, N., Jacquet-Kammerer, S., Bensalah, K., ... Shariat, S. F. (Accepted/In press). Prognostic role of decreased E-cadherin expression in patients with upper tract urothelial carcinoma: a multi-institutional study. World Journal of Urology, 1-8. https://doi.org/10.1007/s00345-016-1835-1