Prognostic value of metabolic tumor volume and total lesion glycolysis from18F-FDG PET/CT in lymph node metastases and risk stratification of endometrial carcinoma

Dou Dou Liu, Jianfang Li, Xiaomao Li, Liangjun Xie, Luping Qin, Fangyu Peng, Mu Hua Cheng

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG), measured by preoperative18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), in risk stratification of patients with endometrial carcinoma (EC). Methods: The patients with pathological diagnosis of EC who underwent preoperative 18 F-FDG PET/CT imaging were retrospectively selected for analysis of the prognostic values of PET parameters in risk classification and lymph node metastases (LNMs). Receiver-operating-characteristic analysis was used to analyze the correlation of PET parameters cutoff values with deep myometrial invasion (MI), lymphovascular space involvement and LNM for prognostic values in risk stratification. Results: The sensitivity, specificity, positive predictive value, negative predictive value and accuracy for detection of LNM are 83.3%, 99.7%, 90.9%, 99.5% and 99.2%, respectively. The MTV and TLG of primary lesion of EC in the patients with LNM are notably higher than those in patients without LNM, p<0.010. The MTV and TLG of the EC primary lesions in high-risk patients are significantly higher than those in low-risk patients (p<0.010), but the maximum standardized uptake value (SUVmax) is not. The MTV and TLG of primary lesions were superior to SUVmax for predicting of deep MI, LNM and high-risk of EC (p<0.005). Conclusion: MTV and TLG of primary lesions are more valuable in predicting risk stratification of EC patients. Preoperative18F-FDG PET/CT imaging is useful in predicting the LNM of EC and may help guide pelvic lymphadenectomy to avoid unnecessary pelvic lymphadenectomy in EC patients with low-risk stratification.

Original languageEnglish (US)
Article numbere89
JournalJournal of Gynecologic Oncology
Volume30
Issue number6
DOIs
StatePublished - Nov 2019

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Glycolysis
Endometrial Neoplasms
Tumor Burden
Lymph Nodes
Neoplasm Metastasis
Lymph Node Excision
Fluorodeoxyglucose F18
ROC Curve
Sensitivity and Specificity

Keywords

  • Endometrial Carcinoma
  • Lymphatic Metastases
  • Metabolism
  • Risk Assessment
  • Tumor Volume

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Cite this

Prognostic value of metabolic tumor volume and total lesion glycolysis from18F-FDG PET/CT in lymph node metastases and risk stratification of endometrial carcinoma. / Liu, Dou Dou; Li, Jianfang; Li, Xiaomao; Xie, Liangjun; Qin, Luping; Peng, Fangyu; Cheng, Mu Hua.

In: Journal of Gynecologic Oncology, Vol. 30, No. 6, e89, 11.2019.

Research output: Contribution to journalArticle

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title = "Prognostic value of metabolic tumor volume and total lesion glycolysis from18F-FDG PET/CT in lymph node metastases and risk stratification of endometrial carcinoma",
abstract = "Objective: To investigate the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG), measured by preoperative18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), in risk stratification of patients with endometrial carcinoma (EC). Methods: The patients with pathological diagnosis of EC who underwent preoperative 18 F-FDG PET/CT imaging were retrospectively selected for analysis of the prognostic values of PET parameters in risk classification and lymph node metastases (LNMs). Receiver-operating-characteristic analysis was used to analyze the correlation of PET parameters cutoff values with deep myometrial invasion (MI), lymphovascular space involvement and LNM for prognostic values in risk stratification. Results: The sensitivity, specificity, positive predictive value, negative predictive value and accuracy for detection of LNM are 83.3{\%}, 99.7{\%}, 90.9{\%}, 99.5{\%} and 99.2{\%}, respectively. The MTV and TLG of primary lesion of EC in the patients with LNM are notably higher than those in patients without LNM, p<0.010. The MTV and TLG of the EC primary lesions in high-risk patients are significantly higher than those in low-risk patients (p<0.010), but the maximum standardized uptake value (SUVmax) is not. The MTV and TLG of primary lesions were superior to SUVmax for predicting of deep MI, LNM and high-risk of EC (p<0.005). Conclusion: MTV and TLG of primary lesions are more valuable in predicting risk stratification of EC patients. Preoperative18F-FDG PET/CT imaging is useful in predicting the LNM of EC and may help guide pelvic lymphadenectomy to avoid unnecessary pelvic lymphadenectomy in EC patients with low-risk stratification.",
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T1 - Prognostic value of metabolic tumor volume and total lesion glycolysis from18F-FDG PET/CT in lymph node metastases and risk stratification of endometrial carcinoma

AU - Liu, Dou Dou

AU - Li, Jianfang

AU - Li, Xiaomao

AU - Xie, Liangjun

AU - Qin, Luping

AU - Peng, Fangyu

AU - Cheng, Mu Hua

PY - 2019/11

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N2 - Objective: To investigate the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG), measured by preoperative18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), in risk stratification of patients with endometrial carcinoma (EC). Methods: The patients with pathological diagnosis of EC who underwent preoperative 18 F-FDG PET/CT imaging were retrospectively selected for analysis of the prognostic values of PET parameters in risk classification and lymph node metastases (LNMs). Receiver-operating-characteristic analysis was used to analyze the correlation of PET parameters cutoff values with deep myometrial invasion (MI), lymphovascular space involvement and LNM for prognostic values in risk stratification. Results: The sensitivity, specificity, positive predictive value, negative predictive value and accuracy for detection of LNM are 83.3%, 99.7%, 90.9%, 99.5% and 99.2%, respectively. The MTV and TLG of primary lesion of EC in the patients with LNM are notably higher than those in patients without LNM, p<0.010. The MTV and TLG of the EC primary lesions in high-risk patients are significantly higher than those in low-risk patients (p<0.010), but the maximum standardized uptake value (SUVmax) is not. The MTV and TLG of primary lesions were superior to SUVmax for predicting of deep MI, LNM and high-risk of EC (p<0.005). Conclusion: MTV and TLG of primary lesions are more valuable in predicting risk stratification of EC patients. Preoperative18F-FDG PET/CT imaging is useful in predicting the LNM of EC and may help guide pelvic lymphadenectomy to avoid unnecessary pelvic lymphadenectomy in EC patients with low-risk stratification.

AB - Objective: To investigate the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG), measured by preoperative18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), in risk stratification of patients with endometrial carcinoma (EC). Methods: The patients with pathological diagnosis of EC who underwent preoperative 18 F-FDG PET/CT imaging were retrospectively selected for analysis of the prognostic values of PET parameters in risk classification and lymph node metastases (LNMs). Receiver-operating-characteristic analysis was used to analyze the correlation of PET parameters cutoff values with deep myometrial invasion (MI), lymphovascular space involvement and LNM for prognostic values in risk stratification. Results: The sensitivity, specificity, positive predictive value, negative predictive value and accuracy for detection of LNM are 83.3%, 99.7%, 90.9%, 99.5% and 99.2%, respectively. The MTV and TLG of primary lesion of EC in the patients with LNM are notably higher than those in patients without LNM, p<0.010. The MTV and TLG of the EC primary lesions in high-risk patients are significantly higher than those in low-risk patients (p<0.010), but the maximum standardized uptake value (SUVmax) is not. The MTV and TLG of primary lesions were superior to SUVmax for predicting of deep MI, LNM and high-risk of EC (p<0.005). Conclusion: MTV and TLG of primary lesions are more valuable in predicting risk stratification of EC patients. Preoperative18F-FDG PET/CT imaging is useful in predicting the LNM of EC and may help guide pelvic lymphadenectomy to avoid unnecessary pelvic lymphadenectomy in EC patients with low-risk stratification.

KW - Endometrial Carcinoma

KW - Lymphatic Metastases

KW - Metabolism

KW - Risk Assessment

KW - Tumor Volume

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