Pronase effect on pancreatic,' beta cell secretion and morphology

L. Orci; M. Amherdt; J. C. Henquin; A. E. Lambert; Roger H Unger; A. E. Resold

doi:10.1126/science.180.4086.647

Pronase effect on pancreatic,' beta cell secretion and morphology

L. Orci, M. Amherdt, J. C. Henquin, A. E. Lambert, Roger H Unger, A. E. Resold

Research output: Contribution to journal › Article › peer-review

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Abstract

Pronase at low concentration (4 micrograins per milliliter) produce a reversible increase of glucose-stimulated insulin release in isolated islets of Langerhans. Pronase also affects the ultrastructure of the beta cells by inducing extensive development of tight junctions as well as the accumulation of secretory product within the extracellular spaces.

Original language	English (US)
Pages (from-to)	647-649
Number of pages	3
Journal	Science
Volume	180
Issue number	4086
DOIs	https://doi.org/10.1126/science.180.4086.647
State	Published - 1973

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title = "Pronase effect on pancreatic,' beta cell secretion and morphology",

abstract = "Pronase at low concentration (4 micrograins per milliliter) produce a reversible increase of glucose-stimulated insulin release in isolated islets of Langerhans. Pronase also affects the ultrastructure of the beta cells by inducing extensive development of tight junctions as well as the accumulation of secretory product within the extracellular spaces.",

author = "L. Orci and M. Amherdt and Henquin, {J. C.} and Lambert, {A. E.} and Unger, {Roger H} and Resold, {A. E.}",

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AU - Orci, L.

AU - Amherdt, M.

AU - Henquin, J. C.

AU - Lambert, A. E.

AU - Unger, Roger H

AU - Resold, A. E.

PY - 1973

Y1 - 1973

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AB - Pronase at low concentration (4 micrograins per milliliter) produce a reversible increase of glucose-stimulated insulin release in isolated islets of Langerhans. Pronase also affects the ultrastructure of the beta cells by inducing extensive development of tight junctions as well as the accumulation of secretory product within the extracellular spaces.

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Pronase effect on pancreatic,' beta cell secretion and morphology

Abstract

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