Pronase effect on pancreatic,' beta cell secretion and morphology

L. Orci, M. Amherdt, J. C. Henquin, A. E. Lambert, Roger H Unger, A. E. Resold

Research output: Contribution to journalArticle

70 Scopus citations


Pronase at low concentration (4 micrograins per milliliter) produce a reversible increase of glucose-stimulated insulin release in isolated islets of Langerhans. Pronase also affects the ultrastructure of the beta cells by inducing extensive development of tight junctions as well as the accumulation of secretory product within the extracellular spaces.

Original languageEnglish (US)
Pages (from-to)647-649
Number of pages3
Issue number4086
StatePublished - Jan 1 1973


ASJC Scopus subject areas

  • General

Cite this

Orci, L., Amherdt, M., Henquin, J. C., Lambert, A. E., Unger, R. H., & Resold, A. E. (1973). Pronase effect on pancreatic,' beta cell secretion and morphology. Science, 180(4086), 647-649.