Prospective Evidence of a Circadian Rhythm for Out-of-Hospital Cardiac Arrests

Robert L. Levine, Paul E. Pepe, Robert E. Fromm, Peter A. Curka, Peter A. Clark

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Objectives. —Published studies have indicated a circadian rhythm in the occurrence of sudden cardiac death. However, these studies have involved either retrospective analyses of death certificates or analyses of data collected during studies of pharmacologic agents in selected populations. Purpose. —To determine whether a circadian pattern could be clearly demonstrated in a prospective study of out-of-hospital sudden cardiac death in a large, unselected population. Design. —All adult cases of sudden death of presumed primary cardiac cause from a large urban population were prospectively evaluated over a 12-month period. The incidence of sudden cardiac death was analyzed using harmonic regression of the data tabulated by hour of the day. Results. —During the year of study, 1019 consecutive primary cardiac arrests were analyzed. A significant circadian pattern was found (P

Original languageEnglish (US)
Pages (from-to)2935-2937
Number of pages3
JournalJAMA - Journal of the American Medical Association
Volume267
Issue number21
DOIs
StatePublished - Jun 3 1992

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Out-of-Hospital Cardiac Arrest
Sudden Cardiac Death
Circadian Rhythm
Death Certificates
Urban Population
Sudden Death
Heart Arrest
Population
Prospective Studies
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Prospective Evidence of a Circadian Rhythm for Out-of-Hospital Cardiac Arrests. / Levine, Robert L.; Pepe, Paul E.; Fromm, Robert E.; Curka, Peter A.; Clark, Peter A.

In: JAMA - Journal of the American Medical Association, Vol. 267, No. 21, 03.06.1992, p. 2935-2937.

Research output: Contribution to journalArticle

Levine, Robert L. ; Pepe, Paul E. ; Fromm, Robert E. ; Curka, Peter A. ; Clark, Peter A. / Prospective Evidence of a Circadian Rhythm for Out-of-Hospital Cardiac Arrests. In: JAMA - Journal of the American Medical Association. 1992 ; Vol. 267, No. 21. pp. 2935-2937.
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