Prostate cancer stem cells

Elaine M. Hurt, George J. Klarmann, Brian T. Kawasaki, Nima Sharifi, William L. Farrar

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Prostate cancer is the leading cancer diagnosed in males. Emerging data suggests that cancer arises from only certain cells, termed cancer stem cells, contained within the prostate. In this chapter we will discuss in depth the prostate cancer stem cell. We detail the properties of both normal prostate stem cells and cancer stem cells and discuss the identification and isolation of the prostate cancer stem cells, including the current knowledge of the surface markers used for identification. Furthermore, we discuss the signaling pathways that are important in stem cell maintenance and comment on what is known about these pathways in prostate cancer stem cells and how these pathways, and others, may be targeted to inhibit or kill the tumor-initiating cancer stem cells. In conclusion, we provide a short discussion on the future directions for study of prostate cancer stem cells.

Original languageEnglish (US)
Title of host publicationStem Cells and Cancer
PublisherSpringer New York
Pages137-165
Number of pages29
ISBN (Print)9780387896106
DOIs
StatePublished - Dec 1 2009

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Hurt, E. M., Klarmann, G. J., Kawasaki, B. T., Sharifi, N., & Farrar, W. L. (2009). Prostate cancer stem cells. In Stem Cells and Cancer (pp. 137-165). Springer New York. https://doi.org/10.1007/978-0-387-89611-3_6