Protective effect of morin on dimethylnitrosamine-induced hepatic fibrosis in rats

Hee Seung Lee, Kyung Hee Jung, In Suh Park, Sung Won Kwon, Don Haeng Lee, Soon Sun Hong

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Morin, a plant-derived flavonoid, has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the protective effect of morin on hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. Oral administration of morin remarkably prevented weight loss in the body and liver from DMN and inhibited the elevation of serum alanine transaminase (ALT), aspartate transaminase (AST), and total bilirubin levels. For the evaluation of hepatic fibrosis-related factors, we investigated expressions of collagen type I, transforming growth factor β1 (TGF-β1), and α-smooth muscle actin (α-SMA) in mRNA and protein levels. We observed that morin significantly reduced the expression of collagen type I, TGF-β1, and α-SMA on hepatic fibrosis induced by DMN. Taken together, this study demonstrated that morin showed hepatoprotective and antifibrogenic effects against DMN-induced hepatic injury. This suggests that morin may be useful in preventing the development of hepatic fibrosis and cirrhosis.

Original languageEnglish (US)
Pages (from-to)782-788
Number of pages7
JournalDigestive Diseases and Sciences
Volume54
Issue number4
DOIs
StatePublished - Apr 1 2009

Keywords

  • Antioxidant
  • Dimethylnitrosamine
  • Hepatic fibrosis
  • Morin

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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