Protein quality control and metabolism

Bidirectional control in the heart

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The prevalence of heart disease, especially heart failure, continues to increase, and cardiovascular disease remains the leading cause of death worldwide. As cardiomyocytes are essentially irreplaceable, protein quality control is pivotal to cellular homeostasis and, ultimately, cardiac performance. Three evolutionarily conserved mechanisms - autophagy, the unfolded protein response, and the ubiquitin-proteasome system - act in concert to degrade misfolded proteins and eliminate defective organelles. Recent advances have revealed that these mechanisms are intimately associated with cellular metabolism. Going forward, comprehensive understanding of the role of protein quality control mechanisms in cardiac pathology will require integration of metabolic pathways and metabolic control.

Original languageEnglish (US)
Pages (from-to)215-226
Number of pages12
JournalCell Metabolism
Volume21
Issue number2
DOIs
StatePublished - Feb 3 2015

Fingerprint

Quality Control
Unfolded Protein Response
Proteins
Autophagy
Proteasome Endopeptidase Complex
Ubiquitin
Metabolic Networks and Pathways
Cardiac Myocytes
Organelles
Cause of Death
Heart Diseases
Homeostasis
Cardiovascular Diseases
Heart Failure
Pathology

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

Cite this

Protein quality control and metabolism : Bidirectional control in the heart. / Wang, Zhao; Hill, Joseph A.

In: Cell Metabolism, Vol. 21, No. 2, 03.02.2015, p. 215-226.

Research output: Contribution to journalArticle

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