Protein sensors for membrane sterols

Research output: Contribution to journalReview article

1032 Scopus citations

Abstract

Cholesterol is an essential component of animal cell membranes, and its concentration is tightly controlled by a feedback system that operates at transcriptional and posttranscriptional levels. Here, we discuss recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake.

Original languageEnglish (US)
Pages (from-to)35-46
Number of pages12
JournalCell
Volume124
Issue number1
DOIs
StatePublished - Jan 13 2006

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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