Proteins with leucine-rich repeats

Bostjan Kobe, Johann Deisenhofer

Research output: Contribution to journalArticle

310 Scopus citations

Abstract

Luecine-rich repeats are short sequence motifs present in over sixty proteins, all of which appear to be involved in protein-protein interactions. The crystal structure of ribonuclease inhibitor demonstrated that the repeats correspond to β-α structural units. The recently determined crystal structure of the ribonuclease A-ribonuclease inhibitor complex suggests the basis for the protein-binding function of leucine-rich repeats.

Original languageEnglish (US)
Pages (from-to)409-416
Number of pages8
JournalCurrent Opinion in Structural Biology
Volume5
Issue number3
DOIs
Publication statusPublished - 1995

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Keywords

  • LPS-lipopolysaccharide
  • LRR-leucine-rich repeat
  • RI-ribonuclease inhibitor

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

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