Pseudocontinuous arterial spin labeling quantifies relative cerebral blood flow in acute stroke

Daymara A. Hernandez, Reinoud P H Bokkers, Raymond V. Mirasol, Marie Luby, Erica C. Henning, José G. Merino, Steven Warach, Lawrence L. Latour

Research output: Contribution to journalArticle

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Abstract

BACKGROUND AND PURPOSE-: The aim of this study was to test whether arterial spin labeling (ASL) can detect significant differences in relative cerebral blood flow (rCBF) in the core, mismatch, and reverse-mismatch regions, and whether rCBF values measured by ASL in those areas differ from values obtained using dynamic susceptibility contrast (DSC) MRI. METHODS-: Acute stroke patients were imaged with diffusion-weighted imaging (DWI) and perfusion-weighted imaging (ASL and DSC) MRI. An expert reader segmented the ischemic lesion on DWI and the DSC time-to-peak (TTP) maps. Three regions were defined: core (DWI+, TTP+), mismatch (DWI-, TTP+), and reverse-mismatch (DWI+, TTP-). For both ASL and DSC, rCBF maps were created with commercially available software, and the ratio was calculated as the mean signal intensity measured on the side of the lesion to that of the homologous region in the contralateral hemisphere. Values obtained from core, mismatch, and reverse-mismatch were used for paired comparison. RESULTS-: Twenty-eight patients were included in the study. The mean age was 65.6 (16.9) years, with a median baseline National Institutes of Health Stroke Scale score of 10 (interquartile range, 4-17). Median time from last known normal to MRI was 5.7 hours (interquartile range, 2.9-22.6). Mean rCBF ratios were significantly higher in the mismatch 0.53 (0.23) versus the core 0.39 (0.33) and reverse-mismatch 0.68 (0.49) versus the core 0.38 (0.35). Differences in rCBF measured with DSC and ASL were not significant. CONCLUSIONS-: ASL allows for the measurement of rCBF in the core and mismatch regions. Values in the mismatch were significantly higher than in the core, suggesting there is potential salvageable tissue.

Original languageEnglish (US)
Pages (from-to)753-758
Number of pages6
JournalStroke
Volume43
Issue number3
DOIs
StatePublished - Mar 2012

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Cerebrovascular Circulation
Stroke
Matched-Pair Analysis
Perfusion Imaging
National Institutes of Health (U.S.)
Software

Keywords

  • acute stroke
  • cerebral blood flow
  • perfusion quantification

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Hernandez, D. A., Bokkers, R. P. H., Mirasol, R. V., Luby, M., Henning, E. C., Merino, J. G., ... Latour, L. L. (2012). Pseudocontinuous arterial spin labeling quantifies relative cerebral blood flow in acute stroke. Stroke, 43(3), 753-758. https://doi.org/10.1161/STROKEAHA.111.635979

Pseudocontinuous arterial spin labeling quantifies relative cerebral blood flow in acute stroke. / Hernandez, Daymara A.; Bokkers, Reinoud P H; Mirasol, Raymond V.; Luby, Marie; Henning, Erica C.; Merino, José G.; Warach, Steven; Latour, Lawrence L.

In: Stroke, Vol. 43, No. 3, 03.2012, p. 753-758.

Research output: Contribution to journalArticle

Hernandez, DA, Bokkers, RPH, Mirasol, RV, Luby, M, Henning, EC, Merino, JG, Warach, S & Latour, LL 2012, 'Pseudocontinuous arterial spin labeling quantifies relative cerebral blood flow in acute stroke', Stroke, vol. 43, no. 3, pp. 753-758. https://doi.org/10.1161/STROKEAHA.111.635979
Hernandez DA, Bokkers RPH, Mirasol RV, Luby M, Henning EC, Merino JG et al. Pseudocontinuous arterial spin labeling quantifies relative cerebral blood flow in acute stroke. Stroke. 2012 Mar;43(3):753-758. https://doi.org/10.1161/STROKEAHA.111.635979
Hernandez, Daymara A. ; Bokkers, Reinoud P H ; Mirasol, Raymond V. ; Luby, Marie ; Henning, Erica C. ; Merino, José G. ; Warach, Steven ; Latour, Lawrence L. / Pseudocontinuous arterial spin labeling quantifies relative cerebral blood flow in acute stroke. In: Stroke. 2012 ; Vol. 43, No. 3. pp. 753-758.
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