Pulmonary Arterial Hypertension

Kelly M. Chin, Lewis J. Rubin

Research output: Contribution to journalReview article

216 Scopus citations

Abstract

Significant advances in the treatment of pulmonary arterial hypertension (PAH) have occurred over the last 10 years, starting with the approval of epoprostenol in 1998. Subsequently, multiple additional medications have received approval, including a subcutaneous prostacyclin, an inhaled prostacyclin, and oral medications in 2 separate classes. Over this same period, the classification of pulmonary hypertension has been revised with changes including the substitution of the term idiopathic for primary PAH and an expanded list of conditions felt to be associated with the development of PAH. Long-term follow-up studies have provided better information on prognosis and expected outcomes with treatment, with particularly valuable data on reassessment of prognosis after treatment with epoprostenol. Combination therapy is more frequently being used, and limited data on novel therapies such as stem cell transplantation have been published. The purpose of this review is to describe the current state of evidence for the diagnosis, prognosis, and treatment of the patient with PAH.

Original languageEnglish (US)
Pages (from-to)1527-1538
Number of pages12
JournalJournal of the American College of Cardiology
Volume51
Issue number16
DOIs
StatePublished - Apr 22 2008

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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