Pulmonary nocardiosis in a multiple myeloma patient treated with proteasome inhibitors

Nikolai P. Mendonca, Deepak K. Kadayakkara, Inga C. Forde, Anastasiia Rudkovaskaia, Zane K. Saul, David J. Lobo

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Objective: Rare co-existance of disease or pathology Background: The use of proteasome inhibitors like Bortezomib to treat multiple myeloma has been associated with increased rates of opportunistic infections, including Nocardia, especially when lymphopenia is present. The prevalence or association of such infections with newer agents like Carfilzomib is not known. Case Report: A 71-year-old man with multiple myeloma presented with a 6-week history of respiratory symptoms and cyclic fevers. He was undergoing chemotherapy with Carfilzomib. Work-up revealed severe lymphopenia and a CT chest showed multiple lung nodules and a mass-like consolidation. He underwent a bronchoscopy, and respiratory cultures grew Nocardia species. He responded well to intravenous antibiotics with resolution of symptoms and CT findings. Conclusions: With the introduction of newer agents like Carfilzomib for the treatment of multiple myeloma, clinicians must maintain a high degree of suspicion for opportunistic infections to achieve early diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)76-78
Number of pages3
JournalAmerican Journal of Case Reports
Volume17
DOIs
StatePublished - Feb 10 2016
Externally publishedYes

Keywords

  • Lymphopenia
  • Multiple myeloma
  • Nocardia
  • Proteasome inhibitors

ASJC Scopus subject areas

  • Medicine(all)

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