Quantitative immunophenotyping of circulating tumor cells in blood using microfluidic screening chip integrated with hyperspectral microscope

A. P. Horton; K. Kumar; H. Liu; L. Cheng; N. Lane; E. Taylor; H. R. Garner; J. W. Uhr; X. J. Zhang

doi:10.1109/SENSOR.2009.5285561

Quantitative immunophenotyping of circulating tumor cells in blood using microfluidic screening chip integrated with hyperspectral microscope

A. P. Horton, K. Kumar, H. Liu, L. Cheng, N. Lane, E. Taylor, H. R. Garner, J. W. Uhr, X. J. Zhang

Immunology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Scopus citations

Abstract

An effective screening test for the early diagnosis of cancer is high on the agenda of oncologists, since early detection increases treatment options and patient prognosis. Using microfluidics and Hyperspectral Imaging Microscopy, we demonstrate the ability to capture and immunophenotype circulating tumor cells (CTCs), which are shed by carcinomas at an early stage and signify the presence of cancer in a patient. The technology presented demonstrates the potential for optofluidic microsystems in advanced point-of-care applications and is envisioned to aid disease prognosis, treatment selection, response monitoring, and development of novel therapies.

Original language	English (US)
Title of host publication	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages	77-80
Number of pages	4
DOIs	https://doi.org/10.1109/SENSOR.2009.5285561
State	Published - 2009
Event	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems - Denver, CO, United States Duration: Jun 21 2009 → Jun 25 2009

Publication series

Name	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

Other

Other	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Country/Territory	United States
City	Denver, CO
Period	6/21/09 → 6/25/09

Keywords

Circulating tumor cell
Hyperspectral analysis
Microfluidics

ASJC Scopus subject areas

Hardware and Architecture
Electrical and Electronic Engineering

Access to Document

10.1109/SENSOR.2009.5285561

Cite this

Horton, A. P., Kumar, K., Liu, H., Cheng, L., Lane, N., Taylor, E., Garner, H. R., Uhr, J. W., & Zhang, X. J. (2009). Quantitative immunophenotyping of circulating tumor cells in blood using microfluidic screening chip integrated with hyperspectral microscope. In TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 77-80). Article 5285561 (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems). https://doi.org/10.1109/SENSOR.2009.5285561

Quantitative immunophenotyping of circulating tumor cells in blood using microfluidic screening chip integrated with hyperspectral microscope. / Horton, A. P.; Kumar, K.; Liu, H. et al.
TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems. 2009. p. 77-80 5285561 (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Horton, AP, Kumar, K, Liu, H, Cheng, L, Lane, N, Taylor, E, Garner, HR, Uhr, JW & Zhang, XJ 2009, Quantitative immunophenotyping of circulating tumor cells in blood using microfluidic screening chip integrated with hyperspectral microscope. in TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems., 5285561, TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems, pp. 77-80, TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems, Denver, CO, United States, 6/21/09. https://doi.org/10.1109/SENSOR.2009.5285561

Horton AP, Kumar K, Liu H, Cheng L, Lane N, Taylor E et al. Quantitative immunophenotyping of circulating tumor cells in blood using microfluidic screening chip integrated with hyperspectral microscope. In TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems. 2009. p. 77-80. 5285561. (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems). doi: 10.1109/SENSOR.2009.5285561

Horton, A. P. ; Kumar, K. ; Liu, H. et al. / Quantitative immunophenotyping of circulating tumor cells in blood using microfluidic screening chip integrated with hyperspectral microscope. TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems. 2009. pp. 77-80 (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems).

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abstract = "An effective screening test for the early diagnosis of cancer is high on the agenda of oncologists, since early detection increases treatment options and patient prognosis. Using microfluidics and Hyperspectral Imaging Microscopy, we demonstrate the ability to capture and immunophenotype circulating tumor cells (CTCs), which are shed by carcinomas at an early stage and signify the presence of cancer in a patient. The technology presented demonstrates the potential for optofluidic microsystems in advanced point-of-care applications and is envisioned to aid disease prognosis, treatment selection, response monitoring, and development of novel therapies.",

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AU - Horton, A. P.

AU - Kumar, K.

AU - Liu, H.

AU - Cheng, L.

AU - Lane, N.

AU - Taylor, E.

AU - Garner, H. R.

AU - Uhr, J. W.

AU - Zhang, X. J.

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AB - An effective screening test for the early diagnosis of cancer is high on the agenda of oncologists, since early detection increases treatment options and patient prognosis. Using microfluidics and Hyperspectral Imaging Microscopy, we demonstrate the ability to capture and immunophenotype circulating tumor cells (CTCs), which are shed by carcinomas at an early stage and signify the presence of cancer in a patient. The technology presented demonstrates the potential for optofluidic microsystems in advanced point-of-care applications and is envisioned to aid disease prognosis, treatment selection, response monitoring, and development of novel therapies.

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KW - Hyperspectral analysis

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Quantitative immunophenotyping of circulating tumor cells in blood using microfluidic screening chip integrated with hyperspectral microscope

Abstract

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Keywords

ASJC Scopus subject areas

Access to Document

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