Quantitative immunophenotyping of circulating tumor cells in blood using microfluidic screening chip integrated with hyperspectral microscope

A. P. Horton, K. Kumar, H. Liu, L. Cheng, N. Lane, E. Taylor, H. R. Garner, J. W. Uhr, X. J. Zhang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

An effective screening test for the early diagnosis of cancer is high on the agenda of oncologists, since early detection increases treatment options and patient prognosis. Using microfluidics and Hyperspectral Imaging Microscopy, we demonstrate the ability to capture and immunophenotype circulating tumor cells (CTCs), which are shed by carcinomas at an early stage and signify the presence of cancer in a patient. The technology presented demonstrates the potential for optofluidic microsystems in advanced point-of-care applications and is envisioned to aid disease prognosis, treatment selection, response monitoring, and development of novel therapies.

Original languageEnglish (US)
Title of host publicationTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages77-80
Number of pages4
DOIs
StatePublished - Dec 11 2009
EventTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems - Denver, CO, United States
Duration: Jun 21 2009Jun 25 2009

Publication series

NameTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

Other

OtherTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
CountryUnited States
CityDenver, CO
Period6/21/096/25/09

Keywords

  • Circulating tumor cell
  • Hyperspectral analysis
  • Microfluidics

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering

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    Horton, A. P., Kumar, K., Liu, H., Cheng, L., Lane, N., Taylor, E., Garner, H. R., Uhr, J. W., & Zhang, X. J. (2009). Quantitative immunophenotyping of circulating tumor cells in blood using microfluidic screening chip integrated with hyperspectral microscope. In TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 77-80). [5285561] (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems). https://doi.org/10.1109/SENSOR.2009.5285561