Quantitative simultaneous In-111/ Tc-99m planar imaging of the foot

X. Zhu, M. A. Park, S. C. Moore

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Tc-99m and In-111-white blood cell (WBC) imaging are useful for discriminating osteomyelitis from cellulitis of the foot. Accurate diagnosis from sequential studies is challenging because the images are not registered and the Tc-99m/In-111 ratio is assessed subjectively. We developed a simultaneous dual-radionuclide imaging method in which Tc-99m scans are acquired in perfect spatial registration with In-111 WBC images. A foot phantom was made using five tubes containing Tc/In activity ratios from 0.13 to 3.80. The tubes were positioned at a shallow angle in a 5-cm-deep water layer. A single tube was first imaged in list-mode over 18 hours, providing a wide range of Tc/In activity ratios for optimizing triple-energy-window (TEW) parameters for scatter and crosstalk correction of both nuclides. Twelve Poisson noise realizations were generated from very low-noise opposed images of the foot phantom. We measured the bias of Tc/In ratios in regions-of-interest (ROIs) on each tube, along with the uniformity and precision of ROI counts for both nuclides, with (cor) and without (uncor) TEW and geometricmean (GM) attenuation compensation. The average uniformity along the tubes improved for Tc from 13% (uncor) to 5.6% (cor), and for In from 12.8% (uncor) to 4.4% (cor). The average absolute bias of the Tc/In ratio over all tubes was 4.5% (cor) vs. 48.4% (uncor), with comparable precision. Simultaneous Tc/In acquisition with TEW+GM corrections provides a useful approach for foot imaging.

Original languageEnglish (US)
Title of host publication2006 IEEE Nuclear Science Symposium - Conference Record
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2684-2687
Number of pages4
ISBN (Print)1424405610, 9781424405619
DOIs
StatePublished - 2006
Externally publishedYes
Event2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD - San Diego, CA, United States
Duration: Oct 29 2006Nov 4 2006

Publication series

NameIEEE Nuclear Science Symposium Conference Record
Volume5
ISSN (Print)1095-7863

Other

Other2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD
CountryUnited States
CitySan Diego, CA
Period10/29/0611/4/06

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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