Rab3A Interacting Molecules (RIMs)

P. S. Kaeser, C. M. Powell

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

RIM proteins are scaffolding molecules at the active zone of central and peripheral nervous system synapses. As a result of their interactions with multiple presynaptic active-zone proteins, synaptic vesicle proteins, and cytosolic proteins, RIMs are necessary for the efficient regulation of neurotransmitter release, short-term synaptic plasticity, and long-term synaptic plasticity. Absence of RIM1. α in knockout mice results in abnormal learning and memory and locomotor response to novelty while sparing other behaviors. This article reviews the molecular, synaptic, and behavioral findings implicating RIM proteins as key presynaptic active-zone molecules that are critical for normal central nervous system function.. .

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages7-14
Number of pages8
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

Keywords

  • Active zone
  • Learning
  • Long-term potentiation
  • Memory
  • Mossy fiber
  • Neurotransmitter
  • Neurotransmitter release
  • Presynaptic
  • Probability of release
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Kaeser, P. S., & Powell, C. M. (2009). Rab3A Interacting Molecules (RIMs). In Encyclopedia of Neuroscience (pp. 7-14). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.01353-X