Radiation sensitivity of human lung cancer cell lines

James Carmichael, William G. Degraff, Janet Gamson, Dylan Russo, Adi F. Gazdar, Mark L. Levitt, John D. Minna, James B. Mitchell

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

X-Ray survival curves were determined using a panel of 17 human lung cancer cell lines, with emphasis on non-small cell lung cancer (NSCLC). In contrast to classic small cell lung cancer (SCLC) cell lines, NSCLC cell lines were generally less sensitive to radiation as evidenced by higher radiation survival curve extrapolation numbers, surviving fraction values following a 2 Gy dose (SF2) and the mean inactivation dose values (D̄) values. The spectrum of in vitro radiation responses observed was similar to that expected in clinical practice, although mesothelioma was unexpectedly sensitive in vitro. Differences in radiosensitivity were best distinguished by comparison of SF2 values. Some NSCLC lines were relatively sensitive, and in view of this demonstrable variability in radiation sensitivity, the SF2 value may be useful for in vitro predictive assay testing of clinical specimens.

Original languageEnglish (US)
Pages (from-to)527-534
Number of pages8
JournalEuropean Journal of Cancer and Clinical Oncology
Volume25
Issue number3
DOIs
StatePublished - 1989

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Radiation Tolerance
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Radiation
Cell Line
Survival
Mesothelioma
Small Cell Lung Carcinoma
X-Rays
In Vitro Techniques

ASJC Scopus subject areas

  • Oncology

Cite this

Carmichael, J., Degraff, W. G., Gamson, J., Russo, D., Gazdar, A. F., Levitt, M. L., ... Mitchell, J. B. (1989). Radiation sensitivity of human lung cancer cell lines. European Journal of Cancer and Clinical Oncology, 25(3), 527-534. https://doi.org/10.1016/0277-5379(89)90266-6

Radiation sensitivity of human lung cancer cell lines. / Carmichael, James; Degraff, William G.; Gamson, Janet; Russo, Dylan; Gazdar, Adi F.; Levitt, Mark L.; Minna, John D.; Mitchell, James B.

In: European Journal of Cancer and Clinical Oncology, Vol. 25, No. 3, 1989, p. 527-534.

Research output: Contribution to journalArticle

Carmichael, J, Degraff, WG, Gamson, J, Russo, D, Gazdar, AF, Levitt, ML, Minna, JD & Mitchell, JB 1989, 'Radiation sensitivity of human lung cancer cell lines', European Journal of Cancer and Clinical Oncology, vol. 25, no. 3, pp. 527-534. https://doi.org/10.1016/0277-5379(89)90266-6
Carmichael J, Degraff WG, Gamson J, Russo D, Gazdar AF, Levitt ML et al. Radiation sensitivity of human lung cancer cell lines. European Journal of Cancer and Clinical Oncology. 1989;25(3):527-534. https://doi.org/10.1016/0277-5379(89)90266-6
Carmichael, James ; Degraff, William G. ; Gamson, Janet ; Russo, Dylan ; Gazdar, Adi F. ; Levitt, Mark L. ; Minna, John D. ; Mitchell, James B. / Radiation sensitivity of human lung cancer cell lines. In: European Journal of Cancer and Clinical Oncology. 1989 ; Vol. 25, No. 3. pp. 527-534.
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