Rapid changes in hepatic glucose output after a pulse of growth hormone in dogs.

P. Vaitkus, A. Sirek, K. H. Norwich, O. V. Sirek, Roger H Unger, V. Harris

Research output: Contribution to journalArticle

9 Scopus citations


In response to a single intravenous injection of bovine growth hormone (GH, 100 micrograms/kg) the non-steady-state turnover of glucose, as well as portal levels of insulin (IRI), glucagon (IRG), somatostatin (SRIF), and glucose were determined in normal conscious dogs. Using the two-compartment model validated to calculate rapid turnover changes and tracer infusion methods, the rate of hepatic output of glucose [Ra(t)] was found to be increased, reaching a maximum of 224 mg/min, 7.4 times the basal rate, 4 min after injection of GH. Ra(t) returned to its basal level 35 min later in a damped oscillatory manner. Hormone determinations were carried out in portal venous blood drawn every 2 min for 2 h from an indwelling catheter. IRG peaked 2 min after GH injection and levels of IRI, SRIF, and glucose peaked between 4 and 8 min. Hormone concentrations returned to normal, i.e., were oscillating around base-line levels, about 30 min after GH. These experiments demonstrate for the first time in vivo that a pulse of GH causes transient changes of glucose turnover and measurable alterations of the hormonal homeostasis in the splanchnic area.

Original languageEnglish (US)
JournalThe American journal of physiology
Issue number1 Pt 1
Publication statusPublished - Jan 1984


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Vaitkus, P., Sirek, A., Norwich, K. H., Sirek, O. V., Unger, R. H., & Harris, V. (1984). Rapid changes in hepatic glucose output after a pulse of growth hormone in dogs. The American journal of physiology, 246(1 Pt 1).