Rapid decline in bone turnover markers but not bone mineral density in acromegalic patients after transsphenoidal surgery

Daisuke Tamada, Tetsuhiro Kitamura, Toshiharu Onodera, Yukiko Tabuchi, Atsunori Fukuhara, Satoru Oshino, Youichi Saitoh, Toshimitsu Hamasaki, Michio Otsuki, Iichiro Shimomura

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Growth hormone (GH) and insulin-like growth factor-I (IGF-I) play important roles in maintaining bone metabolism and bone mineral density (BMD) in adulthood, in addition to stimulating longitudinal bone growth in childhood. However, information on the effect of GH excess on bone metabolism and BMD is incomplete and requires further analysis. The aim of this study is to clarify the effect of rapid decline in GH levels after transsphenoidal surgery (TSS) on bone metabolism in acromegalic patients. In this prospective study, 22 patients (11 males and 11 females) with active acromegaly underwent TSS. Bone formation marker (serum bone alkaline phosphatase: BAP), bone resorption marker (urinary type I collagen cross-linked N-telopeptide: urinary NTx) and BMD were measured before and at 3 and 12 months after TSS. BAP was significantly decreased at 12 months after TSS, but not at 3 months. Urinary NTx was significantly decreased at 3 and 12 months after TSS. BMD did not change after TSS. In conclusion, the rapid fall in GH level after TSS had no effect on BMD for up to 12 months after TSS despite the decrease in markers of bone formation and resorption.

Original languageEnglish (US)
Pages (from-to)231-237
Number of pages7
JournalEndocrine Journal
Volume61
Issue number3
DOIs
StatePublished - 2014

Keywords

  • Acromegaly
  • Bone mineral density
  • Bone turnover marker
  • Transsphenoidal surgery

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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