TY - JOUR
T1 - Rapid decline in bone turnover markers but not bone mineral density in acromegalic patients after transsphenoidal surgery
AU - Tamada, Daisuke
AU - Kitamura, Tetsuhiro
AU - Onodera, Toshiharu
AU - Tabuchi, Yukiko
AU - Fukuhara, Atsunori
AU - Oshino, Satoru
AU - Saitoh, Youichi
AU - Hamasaki, Toshimitsu
AU - Otsuki, Michio
AU - Shimomura, Iichiro
PY - 2014
Y1 - 2014
N2 - Growth hormone (GH) and insulin-like growth factor-I (IGF-I) play important roles in maintaining bone metabolism and bone mineral density (BMD) in adulthood, in addition to stimulating longitudinal bone growth in childhood. However, information on the effect of GH excess on bone metabolism and BMD is incomplete and requires further analysis. The aim of this study is to clarify the effect of rapid decline in GH levels after transsphenoidal surgery (TSS) on bone metabolism in acromegalic patients. In this prospective study, 22 patients (11 males and 11 females) with active acromegaly underwent TSS. Bone formation marker (serum bone alkaline phosphatase: BAP), bone resorption marker (urinary type I collagen cross-linked N-telopeptide: urinary NTx) and BMD were measured before and at 3 and 12 months after TSS. BAP was significantly decreased at 12 months after TSS, but not at 3 months. Urinary NTx was significantly decreased at 3 and 12 months after TSS. BMD did not change after TSS. In conclusion, the rapid fall in GH level after TSS had no effect on BMD for up to 12 months after TSS despite the decrease in markers of bone formation and resorption.
AB - Growth hormone (GH) and insulin-like growth factor-I (IGF-I) play important roles in maintaining bone metabolism and bone mineral density (BMD) in adulthood, in addition to stimulating longitudinal bone growth in childhood. However, information on the effect of GH excess on bone metabolism and BMD is incomplete and requires further analysis. The aim of this study is to clarify the effect of rapid decline in GH levels after transsphenoidal surgery (TSS) on bone metabolism in acromegalic patients. In this prospective study, 22 patients (11 males and 11 females) with active acromegaly underwent TSS. Bone formation marker (serum bone alkaline phosphatase: BAP), bone resorption marker (urinary type I collagen cross-linked N-telopeptide: urinary NTx) and BMD were measured before and at 3 and 12 months after TSS. BAP was significantly decreased at 12 months after TSS, but not at 3 months. Urinary NTx was significantly decreased at 3 and 12 months after TSS. BMD did not change after TSS. In conclusion, the rapid fall in GH level after TSS had no effect on BMD for up to 12 months after TSS despite the decrease in markers of bone formation and resorption.
KW - Acromegaly
KW - Bone mineral density
KW - Bone turnover marker
KW - Transsphenoidal surgery
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U2 - 10.1507/endocrj.EJ13-0387
DO - 10.1507/endocrj.EJ13-0387
M3 - Article
C2 - 24304925
AN - SCOPUS:84897456578
SN - 0918-8959
VL - 61
SP - 231
EP - 237
JO - Endocrine Journal
JF - Endocrine Journal
IS - 3
ER -