Rapid magnetic resonance measurement of global cerebral metabolic rate of oxygen consumption in humans during rest and hypercapnia

Varsha Jain, Michael C. Langham, Thomas F. Floyd, Gaurav Jain, Jeremy F. Magland, Felix W. Wehrli

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The effect of hypercapnia on cerebral metabolic rate of oxygen consumption (CMRO2) has been a subject of intensive investigation and debate. Most applications of hypercapnia are based on the assumption that a mild increase in partial pressure of carbon dioxide has negligible effect on cerebral metabolism. In this study, we sought to further investigate the vascular and metabolic effects of hypercapnia by simultaneously measuring global venous oxygen saturation (Sv O2) and total cerebral blood flow (tCBF), with a temporal resolution of 30 seconds using magnetic resonance susceptometry and phase-contrast techniques in 10 healthy awake adults. While significant increases in Sv O2 and tCBF were observed during hypercapnia (P<0.005), no change in CMRO2 was noted (P<0.05). Additionally, fractional changes in tCBF and end-tidal carbon dioxide (R 2 0.72, P<0.005), as well as baseline Sv O2 and tCBF (R2 0.72, P<0.005), were found to be correlated. The data also suggested a correlation between cerebral vascular reactivity (CVR) and baseline tCBF (R2 0.44, P<0.052). A CVR value of 6.1%1.6%/mm Hg was determined using a linear-fit model. Additionally, an average undershoot of 6.7%4% and 17.1%7% was observed in Sv O2 and tCBF upon recovery from hypercapnia in six subjects.

Original languageEnglish (US)
Pages (from-to)1504-1512
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Volume31
Issue number7
DOIs
StatePublished - Jan 1 2011

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Cerebrovascular Circulation
Hypercapnia
Oxygen Consumption
Magnetic Resonance Spectroscopy
Blood Vessels
Carbon Dioxide
Partial Pressure
Linear Models
Oxygen

Keywords

  • carotid artery
  • cerebral blood flow measurement
  • cerebral hemodynamics
  • energy metabolism
  • MRI

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Rapid magnetic resonance measurement of global cerebral metabolic rate of oxygen consumption in humans during rest and hypercapnia. / Jain, Varsha; Langham, Michael C.; Floyd, Thomas F.; Jain, Gaurav; Magland, Jeremy F.; Wehrli, Felix W.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 31, No. 7, 01.01.2011, p. 1504-1512.

Research output: Contribution to journalArticle

Jain, Varsha ; Langham, Michael C. ; Floyd, Thomas F. ; Jain, Gaurav ; Magland, Jeremy F. ; Wehrli, Felix W. / Rapid magnetic resonance measurement of global cerebral metabolic rate of oxygen consumption in humans during rest and hypercapnia. In: Journal of Cerebral Blood Flow and Metabolism. 2011 ; Vol. 31, No. 7. pp. 1504-1512.
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