Rationally improving LOV domainĝ€"based photoswitches

Devin Strickland, Xiaolan Yao, Grzegorz Gawlak, Michael K. Rosen, Kevin H. Gardner, Tobin R. Sosnick

Research output: Contribution to journalArticle

128 Scopus citations

Abstract

Genetically encoded protein photosensors are promising tools for engineering optical control of cellular behavior; we are only beginning to understand how to couple these light detectors to effectors of choice. Here we report a method that increases the dynamic range of an artificial photoswitch based on the LOV2 domain of Avena sativa phototropin 1 (AsLOV2). This approach can potentially be used to improve many AsLOV2-based photoswitches.

Original languageEnglish (US)
Pages (from-to)623-626
Number of pages4
JournalNature methods
Volume7
Issue number8
DOIs
StatePublished - Aug 1 2010

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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