Recent advances in distal tubular potassium handling

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

It is well known that sodium reabsorption and aldosterone play important roles in potassium secretion by the aldosterone-sensitive distal nephron. Sodium- and aldosterone-independent mechanisms also exist. This review focuses on some recent studies that provide novel insights into the sodium- and aldosterone-independent potassium secretion by the aldosterone-sensitive distal nephron. In addition, we discuss a study reporting on the regulation of the mammalian potassium kidney channel ROMK by intracellular and extracellular magnesium, which may be important in the pathogenesis of persistent hypokalemia in patients with concomitant potassium and magnesium deficiency. We also discuss outstanding questions and propose working models for future investigation.

Original languageEnglish (US)
Pages (from-to)821-827
Number of pages7
JournalAmerican Journal of Physiology - Renal Physiology
Volume300
Issue number4
DOIs
StatePublished - Apr 1 2011

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Aldosterone
Potassium
Sodium
Nephrons
Potassium Deficiency
Magnesium Deficiency
Hypokalemia
Potassium Channels
Magnesium
Kidney

Keywords

  • Adosterone
  • Itercalated cell
  • Maxi-K;
  • ROMK
  • WNK1

ASJC Scopus subject areas

  • Physiology
  • Urology

Cite this

Recent advances in distal tubular potassium handling. / Rodan, Aylin R.; Cheng, Chih Jen; Huang, Chou Long.

In: American Journal of Physiology - Renal Physiology, Vol. 300, No. 4, 01.04.2011, p. 821-827.

Research output: Contribution to journalArticle

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