Recent advances in distal tubular potassium handling

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

It is well known that sodium reabsorption and aldosterone play important roles in potassium secretion by the aldosterone-sensitive distal nephron. Sodium- and aldosterone-independent mechanisms also exist. This review focuses on some recent studies that provide novel insights into the sodium- and aldosterone-independent potassium secretion by the aldosterone-sensitive distal nephron. In addition, we discuss a study reporting on the regulation of the mammalian potassium kidney channel ROMK by intracellular and extracellular magnesium, which may be important in the pathogenesis of persistent hypokalemia in patients with concomitant potassium and magnesium deficiency. We also discuss outstanding questions and propose working models for future investigation.

Original languageEnglish (US)
Pages (from-to)821-827
Number of pages7
JournalAmerican Journal of Physiology - Renal Physiology
Volume300
Issue number4
DOIs
StatePublished - Apr 1 2011

Keywords

  • Adosterone
  • Itercalated cell
  • Maxi-K;
  • ROMK
  • WNK1

ASJC Scopus subject areas

  • Physiology
  • Urology

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