Recent advances in the metabolomic study of bladder cancer

Chandra Sekhar Amara, Venkatrao Vantaku, Yair Lotan, Nagireddy Putluri

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Introduction: Metabolomics is a chemical process, involving the characterization of metabolites and cellular metabolism. Recent studies indicate that numerous metabolic pathways are altered in bladder cancer (BLCA), providing potential targets for improved detection and possible therapeutic intervention. We review recent advances in metabolomics related to BLCA and identify various metabolites that may serve as potential biomarkers for BLCA. Areas covered: In this review, we describe the latest advances in defining the BLCA metabolome and discuss the possible clinical utility of metabolic alterations in BLCA tissues, serum, and urine. In addition, we focus on the metabolic alterations associated with tobacco smoke and racial disparity in BLCA. Expert commentary: Metabolomics is a powerful tool which can shed new light on BLCA development and behavior. Key metabolites may serve as possible markers of BLCA. However, prospective validation will be needed to incorporate these markers into clinical care.

Original languageEnglish (US)
Pages (from-to)315-324
Number of pages10
JournalExpert Review of Proteomics
Volume16
Issue number4
DOIs
StatePublished - Apr 3 2019

Keywords

  • BLCA
  • LC-MS
  • metabolomics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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