TY - JOUR
T1 - Recent progress in dendrimer-based gene delivery systems
AU - Kuang, Tairong
AU - Fu, Dajiong
AU - Chang, Lingqian
AU - Yang, Zhaogang
AU - Chen, Zhou
AU - Jin, Liliang
AU - Chen, Feng
AU - Peng, Xiangfang
N1 - Publisher Copyright:
© 2016 Bentham Science Publishers.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Due to core-shell nanostructures, highly branched and star-shaped macromolecules with three dimensional structural symmetry, dendrimers have been widely used as non-viral vectors in gene delivery. However, the performance of dendrimer-based gene vectors is far from ideal, mainly because of the low transfection efficiency and serious cytotoxicity. Therefore, many researchers focused on how to improve the transfection efficiency and reduce the cytotoxicity in the past decade. In this review, we mainly reported the most recent advances of dendrimer-based gene delivery systems. Several typical types of dendrimers for gene delivery were reviewed in detail, such as poly (amido amine) (PAMAM), poly (propylene imine) (PPI), poly(ether imine), poly-Llysine dendrimers. Recent advances about other types of dendrimer were also briefly mentioned. These advances provide a promising route to improve the transfection efficiency and reduce the toxicity, which also illustrates the direction of the future development of dendrimers in gene delivery.
AB - Due to core-shell nanostructures, highly branched and star-shaped macromolecules with three dimensional structural symmetry, dendrimers have been widely used as non-viral vectors in gene delivery. However, the performance of dendrimer-based gene vectors is far from ideal, mainly because of the low transfection efficiency and serious cytotoxicity. Therefore, many researchers focused on how to improve the transfection efficiency and reduce the cytotoxicity in the past decade. In this review, we mainly reported the most recent advances of dendrimer-based gene delivery systems. Several typical types of dendrimers for gene delivery were reviewed in detail, such as poly (amido amine) (PAMAM), poly (propylene imine) (PPI), poly(ether imine), poly-Llysine dendrimers. Recent advances about other types of dendrimer were also briefly mentioned. These advances provide a promising route to improve the transfection efficiency and reduce the toxicity, which also illustrates the direction of the future development of dendrimers in gene delivery.
KW - Cytotoxicity
KW - Dendrimers
KW - Gene delivery
KW - Non-viral vectors
KW - Transfection efficiency
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U2 - 10.2174/1385272820666151123235059
DO - 10.2174/1385272820666151123235059
M3 - Review article
AN - SCOPUS:84975729759
SN - 1385-2728
VL - 20
SP - 1820
EP - 1826
JO - Current Organic Chemistry
JF - Current Organic Chemistry
IS - 17
ER -