Receptor activator of nuclear factor-κB ligand (RANKL) and its relationship to coronary atherosclerosis in HIV patients

Janice J. Hwang, Jeffrey Wei, Suhny Abbara, Steven K. Grinspoon, Janet Lo

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

HIV-infected individuals have an increased prevalence of coronary artery disease. Receptor activator of nuclear factor-kB ligand (RANKL) and osteoprotegerin have been postulated as mediators of vascular calcification. 78 HIV-infected men and 32 healthy controls without history of coronary artery disease were prospectively recruited to undergo cardiac computed tomography and computed tomography angiography to assess coronary artery calcium and plaque burden. Soluble receptor activator of nuclear factor-kB ligand was lower in HIV-infected individuals than controls [2.52 (1.08-3.98) vs. 3.33 (2.44-4.64) pg/mL, P = 0.01, median (IQR) respectively]. Soluble receptor activator of nuclear factor-kB ligand was negatively associated with the number of coronary segments with plaque (Spearman ρ = -0.41, P < 0.001) and Agatston calcium score (ρ = -0.30, P < 0.01) in HIV-infected individuals even after adjusting for traditional cardiovascular risk factors.

Original languageEnglish (US)
Pages (from-to)359-363
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume61
Issue number3
DOIs
StatePublished - Jul 26 2012

Keywords

  • Atherosclerosis
  • Coronary artery disease
  • HIV
  • Osteoprotegerin
  • Receptor activator of nuclear factor kappa β ligand

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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