Recognition of Toxoplasma gondii by TLR11 prevents parasite-induced immunopathology

Felix Yarovinsky, Sara Hieny, Alan Sher

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

TLRs are thought to play a critical role in self/non-self discrimination by sensing microbial infections and initiating both innate and adaptive immunity. In this study, we demonstrate that in the absence of TLR11, a major TLR involved in recognition of Toxoplasma gondii, infection with this protozoan parasite induces an abnormal immunopathological response consisting of pancreatic tissue destruction, fat necrosis, and systemic elevations in inflammatory reactants. We further show that this immunopathology is the result of non-TLR dependent activation of IFN-γ secretion by NK cells in response to the infection. These findings reveal that in addition to triggering host resistance to infection, TLR recognition can be critical for the prevention of pathogen-induced immune destruction of self tissue.

Original languageEnglish (US)
Pages (from-to)8478-8484
Number of pages7
JournalJournal of Immunology
Volume181
Issue number12
StatePublished - Dec 15 2008

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Toxoplasma
Parasites
Infection
Fat Necrosis
Toxoplasmosis
Adaptive Immunity
Innate Immunity
Natural Killer Cells

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

Cite this

Yarovinsky, F., Hieny, S., & Sher, A. (2008). Recognition of Toxoplasma gondii by TLR11 prevents parasite-induced immunopathology. Journal of Immunology, 181(12), 8478-8484.

Recognition of Toxoplasma gondii by TLR11 prevents parasite-induced immunopathology. / Yarovinsky, Felix; Hieny, Sara; Sher, Alan.

In: Journal of Immunology, Vol. 181, No. 12, 15.12.2008, p. 8478-8484.

Research output: Contribution to journalArticle

Yarovinsky, F, Hieny, S & Sher, A 2008, 'Recognition of Toxoplasma gondii by TLR11 prevents parasite-induced immunopathology', Journal of Immunology, vol. 181, no. 12, pp. 8478-8484.
Yarovinsky, Felix ; Hieny, Sara ; Sher, Alan. / Recognition of Toxoplasma gondii by TLR11 prevents parasite-induced immunopathology. In: Journal of Immunology. 2008 ; Vol. 181, No. 12. pp. 8478-8484.
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