TY - JOUR
T1 - Recognition of Toxoplasma gondii by TLR11 prevents parasite-induced immunopathology
AU - Yarovinsky, Felix
AU - Hieny, Sara
AU - Sher, Alan
PY - 2008/12/15
Y1 - 2008/12/15
N2 - TLRs are thought to play a critical role in self/non-self discrimination by sensing microbial infections and initiating both innate and adaptive immunity. In this study, we demonstrate that in the absence of TLR11, a major TLR involved in recognition of Toxoplasma gondii, infection with this protozoan parasite induces an abnormal immunopathological response consisting of pancreatic tissue destruction, fat necrosis, and systemic elevations in inflammatory reactants. We further show that this immunopathology is the result of non-TLR dependent activation of IFN-γ secretion by NK cells in response to the infection. These findings reveal that in addition to triggering host resistance to infection, TLR recognition can be critical for the prevention of pathogen-induced immune destruction of self tissue.
AB - TLRs are thought to play a critical role in self/non-self discrimination by sensing microbial infections and initiating both innate and adaptive immunity. In this study, we demonstrate that in the absence of TLR11, a major TLR involved in recognition of Toxoplasma gondii, infection with this protozoan parasite induces an abnormal immunopathological response consisting of pancreatic tissue destruction, fat necrosis, and systemic elevations in inflammatory reactants. We further show that this immunopathology is the result of non-TLR dependent activation of IFN-γ secretion by NK cells in response to the infection. These findings reveal that in addition to triggering host resistance to infection, TLR recognition can be critical for the prevention of pathogen-induced immune destruction of self tissue.
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U2 - 10.4049/jimmunol.181.12.8478
DO - 10.4049/jimmunol.181.12.8478
M3 - Article
C2 - 19050265
AN - SCOPUS:58849160457
SN - 0022-1767
VL - 181
SP - 8478
EP - 8484
JO - Journal of Immunology
JF - Journal of Immunology
IS - 12
ER -