Recovery after ischemic stroke: Criteria for good outcome by level of disability at day 7

Hen Hallevi, Karen C. Albright, Sheryl B. Martin-Schild, Andrew D. Barreto, Miriam M. Morales, Natan Bornstein, Nneka L. Ifejika, Ashfaq Shuaib, James C. Grotta, Sean I. Savitz

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Ischemic stroke is a leading cause of morbidity. Assessing the chances of recovery is critical to optimize poststroke care. Methods: We used a cohort of patients from the Virtual International Stroke Trial Archive that participated in acute stroke trials (control arm) and were followed for 90 days. The cohort was grouped by day 7 (D7) modified Rankin scale (mRS) scores. Variables that were associated with good outcome (mRS 0-2 at 90 days) in the univariate analysis were entered into a logistic regression model to determine the independent good outcome criteria for each D7 mRS tier. Results: We analyzed 1,798 patients. The independent good outcome criteria identified for different mRS tiers were: D7 mRS of 3: age ≤70, 0-2 vascular risk factors, D7 NIH Stroke Scale (NIHSS) arm strength ≤1, D7 NIHSS language score = 0; D7 mRS of 4: age ≤70, male, D7 NIHSS facial palsy ≤1, D7 NIHSS visual = 0, D7 NIHSS leg strength ≤1, D7 NIHSS dysarthria = 0; D7 mRS of 5: age ≤70, IV tPA treatment, D7 NIHSS dysarthria = 0, D7 NIHSS leg strength ≤2. For each mRS tier, we observed a graded increase in the percentage of the primary and secondary end points with increase in the number of criteria. Conclusions: We identified clinical variables that predict good outcome, are specific to each day 7 mRS tier, and enable easy and informative assessment of the patient's likelihood of achieving varying degrees of recovery at day 90. These results may be useful in both clinical practice and research but require validation in an independent patient cohort.

Original languageEnglish (US)
Pages (from-to)341-348
Number of pages8
JournalCerebrovascular Diseases
Volume28
Issue number4
DOIs
StatePublished - Sep 1 2009
Externally publishedYes

Fingerprint

Stroke
Dysarthria
Leg
Arm
Logistic Models
Facial Paralysis
Language
Morbidity
Research

Keywords

  • Level of disability, stroke
  • Outcome, stroke
  • Recovery after ischemic stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Hallevi, H., Albright, K. C., Martin-Schild, S. B., Barreto, A. D., Morales, M. M., Bornstein, N., ... Savitz, S. I. (2009). Recovery after ischemic stroke: Criteria for good outcome by level of disability at day 7. Cerebrovascular Diseases, 28(4), 341-348. https://doi.org/10.1159/000229552

Recovery after ischemic stroke : Criteria for good outcome by level of disability at day 7. / Hallevi, Hen; Albright, Karen C.; Martin-Schild, Sheryl B.; Barreto, Andrew D.; Morales, Miriam M.; Bornstein, Natan; Ifejika, Nneka L.; Shuaib, Ashfaq; Grotta, James C.; Savitz, Sean I.

In: Cerebrovascular Diseases, Vol. 28, No. 4, 01.09.2009, p. 341-348.

Research output: Contribution to journalArticle

Hallevi, H, Albright, KC, Martin-Schild, SB, Barreto, AD, Morales, MM, Bornstein, N, Ifejika, NL, Shuaib, A, Grotta, JC & Savitz, SI 2009, 'Recovery after ischemic stroke: Criteria for good outcome by level of disability at day 7', Cerebrovascular Diseases, vol. 28, no. 4, pp. 341-348. https://doi.org/10.1159/000229552
Hallevi H, Albright KC, Martin-Schild SB, Barreto AD, Morales MM, Bornstein N et al. Recovery after ischemic stroke: Criteria for good outcome by level of disability at day 7. Cerebrovascular Diseases. 2009 Sep 1;28(4):341-348. https://doi.org/10.1159/000229552
Hallevi, Hen ; Albright, Karen C. ; Martin-Schild, Sheryl B. ; Barreto, Andrew D. ; Morales, Miriam M. ; Bornstein, Natan ; Ifejika, Nneka L. ; Shuaib, Ashfaq ; Grotta, James C. ; Savitz, Sean I. / Recovery after ischemic stroke : Criteria for good outcome by level of disability at day 7. In: Cerebrovascular Diseases. 2009 ; Vol. 28, No. 4. pp. 341-348.
@article{3362d527f2424724a759edc3e8d22fe0,
title = "Recovery after ischemic stroke: Criteria for good outcome by level of disability at day 7",
abstract = "Background: Ischemic stroke is a leading cause of morbidity. Assessing the chances of recovery is critical to optimize poststroke care. Methods: We used a cohort of patients from the Virtual International Stroke Trial Archive that participated in acute stroke trials (control arm) and were followed for 90 days. The cohort was grouped by day 7 (D7) modified Rankin scale (mRS) scores. Variables that were associated with good outcome (mRS 0-2 at 90 days) in the univariate analysis were entered into a logistic regression model to determine the independent good outcome criteria for each D7 mRS tier. Results: We analyzed 1,798 patients. The independent good outcome criteria identified for different mRS tiers were: D7 mRS of 3: age ≤70, 0-2 vascular risk factors, D7 NIH Stroke Scale (NIHSS) arm strength ≤1, D7 NIHSS language score = 0; D7 mRS of 4: age ≤70, male, D7 NIHSS facial palsy ≤1, D7 NIHSS visual = 0, D7 NIHSS leg strength ≤1, D7 NIHSS dysarthria = 0; D7 mRS of 5: age ≤70, IV tPA treatment, D7 NIHSS dysarthria = 0, D7 NIHSS leg strength ≤2. For each mRS tier, we observed a graded increase in the percentage of the primary and secondary end points with increase in the number of criteria. Conclusions: We identified clinical variables that predict good outcome, are specific to each day 7 mRS tier, and enable easy and informative assessment of the patient's likelihood of achieving varying degrees of recovery at day 90. These results may be useful in both clinical practice and research but require validation in an independent patient cohort.",
keywords = "Level of disability, stroke, Outcome, stroke, Recovery after ischemic stroke",
author = "Hen Hallevi and Albright, {Karen C.} and Martin-Schild, {Sheryl B.} and Barreto, {Andrew D.} and Morales, {Miriam M.} and Natan Bornstein and Ifejika, {Nneka L.} and Ashfaq Shuaib and Grotta, {James C.} and Savitz, {Sean I.}",
year = "2009",
month = "9",
day = "1",
doi = "10.1159/000229552",
language = "English (US)",
volume = "28",
pages = "341--348",
journal = "Cerebrovascular Diseases",
issn = "1015-9770",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Recovery after ischemic stroke

T2 - Criteria for good outcome by level of disability at day 7

AU - Hallevi, Hen

AU - Albright, Karen C.

AU - Martin-Schild, Sheryl B.

AU - Barreto, Andrew D.

AU - Morales, Miriam M.

AU - Bornstein, Natan

AU - Ifejika, Nneka L.

AU - Shuaib, Ashfaq

AU - Grotta, James C.

AU - Savitz, Sean I.

PY - 2009/9/1

Y1 - 2009/9/1

N2 - Background: Ischemic stroke is a leading cause of morbidity. Assessing the chances of recovery is critical to optimize poststroke care. Methods: We used a cohort of patients from the Virtual International Stroke Trial Archive that participated in acute stroke trials (control arm) and were followed for 90 days. The cohort was grouped by day 7 (D7) modified Rankin scale (mRS) scores. Variables that were associated with good outcome (mRS 0-2 at 90 days) in the univariate analysis were entered into a logistic regression model to determine the independent good outcome criteria for each D7 mRS tier. Results: We analyzed 1,798 patients. The independent good outcome criteria identified for different mRS tiers were: D7 mRS of 3: age ≤70, 0-2 vascular risk factors, D7 NIH Stroke Scale (NIHSS) arm strength ≤1, D7 NIHSS language score = 0; D7 mRS of 4: age ≤70, male, D7 NIHSS facial palsy ≤1, D7 NIHSS visual = 0, D7 NIHSS leg strength ≤1, D7 NIHSS dysarthria = 0; D7 mRS of 5: age ≤70, IV tPA treatment, D7 NIHSS dysarthria = 0, D7 NIHSS leg strength ≤2. For each mRS tier, we observed a graded increase in the percentage of the primary and secondary end points with increase in the number of criteria. Conclusions: We identified clinical variables that predict good outcome, are specific to each day 7 mRS tier, and enable easy and informative assessment of the patient's likelihood of achieving varying degrees of recovery at day 90. These results may be useful in both clinical practice and research but require validation in an independent patient cohort.

AB - Background: Ischemic stroke is a leading cause of morbidity. Assessing the chances of recovery is critical to optimize poststroke care. Methods: We used a cohort of patients from the Virtual International Stroke Trial Archive that participated in acute stroke trials (control arm) and were followed for 90 days. The cohort was grouped by day 7 (D7) modified Rankin scale (mRS) scores. Variables that were associated with good outcome (mRS 0-2 at 90 days) in the univariate analysis were entered into a logistic regression model to determine the independent good outcome criteria for each D7 mRS tier. Results: We analyzed 1,798 patients. The independent good outcome criteria identified for different mRS tiers were: D7 mRS of 3: age ≤70, 0-2 vascular risk factors, D7 NIH Stroke Scale (NIHSS) arm strength ≤1, D7 NIHSS language score = 0; D7 mRS of 4: age ≤70, male, D7 NIHSS facial palsy ≤1, D7 NIHSS visual = 0, D7 NIHSS leg strength ≤1, D7 NIHSS dysarthria = 0; D7 mRS of 5: age ≤70, IV tPA treatment, D7 NIHSS dysarthria = 0, D7 NIHSS leg strength ≤2. For each mRS tier, we observed a graded increase in the percentage of the primary and secondary end points with increase in the number of criteria. Conclusions: We identified clinical variables that predict good outcome, are specific to each day 7 mRS tier, and enable easy and informative assessment of the patient's likelihood of achieving varying degrees of recovery at day 90. These results may be useful in both clinical practice and research but require validation in an independent patient cohort.

KW - Level of disability, stroke

KW - Outcome, stroke

KW - Recovery after ischemic stroke

UR - http://www.scopus.com/inward/record.url?scp=67651006009&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651006009&partnerID=8YFLogxK

U2 - 10.1159/000229552

DO - 10.1159/000229552

M3 - Article

C2 - 19628935

AN - SCOPUS:67651006009

VL - 28

SP - 341

EP - 348

JO - Cerebrovascular Diseases

JF - Cerebrovascular Diseases

SN - 1015-9770

IS - 4

ER -