Recurrence of focal segmental glomerulosclerosis in renal allograft: An in-depth review

Modini Vinai, Pamela Waber, Mouin G. Seikaly

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Focal segmental glomerulosclerosis is a major cause of chronic kidney disease requiring transplantation in children. Recurrence rate in the renal allograft transplantation is as high as 50%. Recurrence of FSGS is associated with renal dysfunction and early graft loss. To date, there is no established therapy for recurrent FSGS after renal transplant. We have reviewed the current English literature in order to summarize current practices with emphasis on graft outcome. We conclude that despite multiple approaches to the post transplant management of recurrent FSGS, none have been shown to be consistently beneficial. Currently, pheresis combined with high dose anti-calcineurin with or without rituximab seems to be the most promising. Further controlled studies are needed to define the optimal therapeutic regimens to treat recurrent of FSGS.

Original languageEnglish (US)
Pages (from-to)314-325
Number of pages12
JournalPediatric Transplantation
Volume14
Issue number3
DOIs
StatePublished - May 2010

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Keywords

  • Children
  • FSGS
  • Kidney
  • Recurrence
  • Transplant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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