Recurrent urinary tract infections in healthy and nonpregnant women

Matthew Glover, Cristiano G. Moreira, Vanessa Sperandio, Philippe Zimmern

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Recurrent urinary tract infections (RUTI) are prevalent and pose significant clinical challenges. Although the term RUTI has long been vaguely defined, a consensus definition has emerged in recent years. The exact etiology behind RUTI remains under debate, with valid arguments for both ascending reinfections as well as persistent infection inside the bladder. These persistent infections exist in the form of quiescent intracellular reservoirs in the mouse model and may represent a novel concept to explain UTI recurrence in humans. Manageable risk factors such as behavioral patterns alongside nonmanageable risk factors including genetic susceptibility are growing fields of investigation. Acute UTI have been studied through two model bacterial strains: Escherichia coli UTI89 and CFT073. However, the clinical relevance to RUTI of these two strains has not been firmly established. Current treatment strategies for RUTI are limited and remain dominated by antibiotic usage despite variable efficacy. The majority of studies in humans have focused on younger groups of women with little information available about the postmenopausal population despite a heightened risk of RUTI in this age group.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalUrological Science
Volume25
Issue number1
DOIs
StatePublished - 2014

Fingerprint

Urinary Tract Infections
Genetic Predisposition to Disease
Infection
Urinary Bladder
Age Groups
Escherichia coli
Anti-Bacterial Agents
Recurrence
Population

Keywords

  • Intracellular bacterial communities
  • Postmenopausal women
  • Quiescent intracellular reservoir
  • Recurrent urinary tract infections
  • Reinfection
  • Risk factors for urinary tract infections

ASJC Scopus subject areas

  • Urology

Cite this

Recurrent urinary tract infections in healthy and nonpregnant women. / Glover, Matthew; Moreira, Cristiano G.; Sperandio, Vanessa; Zimmern, Philippe.

In: Urological Science, Vol. 25, No. 1, 2014, p. 1-8.

Research output: Contribution to journalArticle

@article{586acff9b01e4c6cb5ae1e2f36a8b047,
title = "Recurrent urinary tract infections in healthy and nonpregnant women",
abstract = "Recurrent urinary tract infections (RUTI) are prevalent and pose significant clinical challenges. Although the term RUTI has long been vaguely defined, a consensus definition has emerged in recent years. The exact etiology behind RUTI remains under debate, with valid arguments for both ascending reinfections as well as persistent infection inside the bladder. These persistent infections exist in the form of quiescent intracellular reservoirs in the mouse model and may represent a novel concept to explain UTI recurrence in humans. Manageable risk factors such as behavioral patterns alongside nonmanageable risk factors including genetic susceptibility are growing fields of investigation. Acute UTI have been studied through two model bacterial strains: Escherichia coli UTI89 and CFT073. However, the clinical relevance to RUTI of these two strains has not been firmly established. Current treatment strategies for RUTI are limited and remain dominated by antibiotic usage despite variable efficacy. The majority of studies in humans have focused on younger groups of women with little information available about the postmenopausal population despite a heightened risk of RUTI in this age group.",
keywords = "Intracellular bacterial communities, Postmenopausal women, Quiescent intracellular reservoir, Recurrent urinary tract infections, Reinfection, Risk factors for urinary tract infections",
author = "Matthew Glover and Moreira, {Cristiano G.} and Vanessa Sperandio and Philippe Zimmern",
year = "2014",
doi = "10.1016/j.urols.2013.11.007",
language = "English (US)",
volume = "25",
pages = "1--8",
journal = "Urological Science",
issn = "1879-5226",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Recurrent urinary tract infections in healthy and nonpregnant women

AU - Glover, Matthew

AU - Moreira, Cristiano G.

AU - Sperandio, Vanessa

AU - Zimmern, Philippe

PY - 2014

Y1 - 2014

N2 - Recurrent urinary tract infections (RUTI) are prevalent and pose significant clinical challenges. Although the term RUTI has long been vaguely defined, a consensus definition has emerged in recent years. The exact etiology behind RUTI remains under debate, with valid arguments for both ascending reinfections as well as persistent infection inside the bladder. These persistent infections exist in the form of quiescent intracellular reservoirs in the mouse model and may represent a novel concept to explain UTI recurrence in humans. Manageable risk factors such as behavioral patterns alongside nonmanageable risk factors including genetic susceptibility are growing fields of investigation. Acute UTI have been studied through two model bacterial strains: Escherichia coli UTI89 and CFT073. However, the clinical relevance to RUTI of these two strains has not been firmly established. Current treatment strategies for RUTI are limited and remain dominated by antibiotic usage despite variable efficacy. The majority of studies in humans have focused on younger groups of women with little information available about the postmenopausal population despite a heightened risk of RUTI in this age group.

AB - Recurrent urinary tract infections (RUTI) are prevalent and pose significant clinical challenges. Although the term RUTI has long been vaguely defined, a consensus definition has emerged in recent years. The exact etiology behind RUTI remains under debate, with valid arguments for both ascending reinfections as well as persistent infection inside the bladder. These persistent infections exist in the form of quiescent intracellular reservoirs in the mouse model and may represent a novel concept to explain UTI recurrence in humans. Manageable risk factors such as behavioral patterns alongside nonmanageable risk factors including genetic susceptibility are growing fields of investigation. Acute UTI have been studied through two model bacterial strains: Escherichia coli UTI89 and CFT073. However, the clinical relevance to RUTI of these two strains has not been firmly established. Current treatment strategies for RUTI are limited and remain dominated by antibiotic usage despite variable efficacy. The majority of studies in humans have focused on younger groups of women with little information available about the postmenopausal population despite a heightened risk of RUTI in this age group.

KW - Intracellular bacterial communities

KW - Postmenopausal women

KW - Quiescent intracellular reservoir

KW - Recurrent urinary tract infections

KW - Reinfection

KW - Risk factors for urinary tract infections

UR - http://www.scopus.com/inward/record.url?scp=84896543995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896543995&partnerID=8YFLogxK

U2 - 10.1016/j.urols.2013.11.007

DO - 10.1016/j.urols.2013.11.007

M3 - Article

VL - 25

SP - 1

EP - 8

JO - Urological Science

JF - Urological Science

SN - 1879-5226

IS - 1

ER -