TY - JOUR
T1 - Reduced spontaneous sympathetic nerve activity in multiple sclerosis patients
AU - Keller, David M.
AU - Fadel, Paul J.
AU - Harnsberger, Melissa A.
AU - Remington, Gina M.
AU - Frohman, Elliot
AU - Davis, Scott L.
N1 - Funding Information:
This study was supported by National Heart, Lung, and Blood Institute grant R15HL117224 (S. L. Davis) and National Multiple Sclerosis Society grants RG4696A3/2 (S. L. Davis) and PP1440 (S. L. Davis).
PY - 2014/9/15
Y1 - 2014/9/15
N2 - For the first time, we obtained direct intra-neural measurements of muscle sympathetic nerve activity (MSNA) in relapsing-remitting multiple sclerosis (MS) patients to test the hypothesis that spontaneous resting MSNA is reduced in MS patients compared to age, sex-matched healthy controls. Spontaneous MSNA (microneurography; peroneal nerve), plasma norepinephrine, arterial blood pressure (finger photoplethysmography), and heart rate were measured at rest in three groups: 1) relapsing-remitting MS patients on disease modifying therapy only (MS-DT; n = 6); 2) relapsing-remitting MS patients on disease modifying therapy and medications for MS-related symptoms that are known to effect the central nervous system (MS-DT/ST; n = 5), and 3) healthy age and sex-matched controls (CON; n = 6). Compared to the CON group, MSNA burst frequency (bursts/min) was significantly lower in both MS-DT (P = 0.027) and MS-DT/ST groups (P = 0.003). Similarly, MSNA burst incidence (bursts/100 heartbeats) was significantly reduced in both MS-DT (P = 0.049) and MS-DT/ST groups (P = 0.004) compared to the CON group. Burst frequency and burst incidence were not different between MS-DT and MS-DT/ST groups. Resting plasma norepinephrine was also significantly lower in both MS-DT (P = 0.039) and MS-DT/ST groups (P = 0.021) compared to the CON group. Reduced MSNA may signify an important dysfunction in autonomic control of cardiovascular function in patients with MS.
AB - For the first time, we obtained direct intra-neural measurements of muscle sympathetic nerve activity (MSNA) in relapsing-remitting multiple sclerosis (MS) patients to test the hypothesis that spontaneous resting MSNA is reduced in MS patients compared to age, sex-matched healthy controls. Spontaneous MSNA (microneurography; peroneal nerve), plasma norepinephrine, arterial blood pressure (finger photoplethysmography), and heart rate were measured at rest in three groups: 1) relapsing-remitting MS patients on disease modifying therapy only (MS-DT; n = 6); 2) relapsing-remitting MS patients on disease modifying therapy and medications for MS-related symptoms that are known to effect the central nervous system (MS-DT/ST; n = 5), and 3) healthy age and sex-matched controls (CON; n = 6). Compared to the CON group, MSNA burst frequency (bursts/min) was significantly lower in both MS-DT (P = 0.027) and MS-DT/ST groups (P = 0.003). Similarly, MSNA burst incidence (bursts/100 heartbeats) was significantly reduced in both MS-DT (P = 0.049) and MS-DT/ST groups (P = 0.004) compared to the CON group. Burst frequency and burst incidence were not different between MS-DT and MS-DT/ST groups. Resting plasma norepinephrine was also significantly lower in both MS-DT (P = 0.039) and MS-DT/ST groups (P = 0.021) compared to the CON group. Reduced MSNA may signify an important dysfunction in autonomic control of cardiovascular function in patients with MS.
KW - Autonomic dysfunction
KW - Blood pressure
KW - Microneurography
KW - Muscle sympathetic nerve activity
KW - Peripheral vasculature
KW - Plasma norepinephrine
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U2 - 10.1016/j.jns.2014.06.053
DO - 10.1016/j.jns.2014.06.053
M3 - Article
C2 - 25034056
AN - SCOPUS:84906794964
SN - 0022-510X
VL - 344
SP - 210
EP - 214
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -