Reductions in platelet force development by cardiopulmonary bypass are associated with hemorrhage

P. E. Greilich, M. E. Carr, S. L. Carr, A. S. Chang

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Quantitative assessment of platelet dysfunction after cardiopulmonary bypass (CPB) and prediction of excessive microvascular bleeding remain elusive goals. We used a sensitive instrument capable of simultaneously measuring the force generated by platelets during plasma clot retraction and global dot strength. We hypothesized that CPB would significantly reduce these two variables. Platelet-rich plasma was obtained from eight patients undergoing aortocoronary revascularization prior to induction, after 90 min of CPB, and after protamine administration. Platelet force development was measured using a standardized technique that controlled for platelet number and permitted clot formation in the presence of heparin. Despite the presence of a measurable elastic modulus, platelet force development during bypass was abolished. Peak platelet force development after CPB was significantly lower than before CPB (5255 ± 955 dynes vs 11,600 ± 780 dynes, P = 0.01). The percent recovery (after/before bypass) of peak platelet force development inversely correlated with tube thoracostomy drainage during the first 24 h after placement (r(s) = -0.71, P = 0.048). This study demonstrates that CPB has dramatic effects on platelet force development. The correlation between the percent recovery of peak platelet force development and blood loss supports the clinical relevance of this measurement.

Original languageEnglish (US)
Pages (from-to)459-465
Number of pages7
JournalAnesthesia and Analgesia
Volume80
Issue number3
DOIs
StatePublished - 1995

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Cardiopulmonary Bypass
Blood Platelets
Hemorrhage
Clot Retraction
Thoracostomy
Protamines
Platelet-Rich Plasma
Elastic Modulus
Platelet Count
Heparin
Drainage

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Reductions in platelet force development by cardiopulmonary bypass are associated with hemorrhage. / Greilich, P. E.; Carr, M. E.; Carr, S. L.; Chang, A. S.

In: Anesthesia and Analgesia, Vol. 80, No. 3, 1995, p. 459-465.

Research output: Contribution to journalArticle

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