Reelin, lipoprotein receptors and synaptic plasticity

Joachim Herz, Ying Chen

Research output: Contribution to journalArticle

358 Citations (Scopus)

Abstract

Apolipoprotein E (APOE) is a cholesterol transport protein and an isoform-specific major risk factor for neurodegenerative diseases. The lipoprotein receptors that bind APOE have recently been recognized as pivotal components of the neuronal signalling machinery. The interaction between APOE receptors and one of their ligands, reelin, allows them to function directly as signal transduction receptors at the plasma membrane to control not only neuronal positioning during brain development, but also synaptic plasticity in the adult brain. Here, we review the molecular mechanisms through which APOE, cholesterol, reelin and APOE receptors control synaptic functions that are essential for cognition, learning, memory, behaviour and neuronal survival.

Original languageEnglish (US)
Pages (from-to)850-859
Number of pages10
JournalNature Reviews Neuroscience
Volume7
Issue number11
DOIs
StatePublished - Nov 2006

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Lipoprotein Receptors
Neuronal Plasticity
Apolipoproteins E
Low Density Lipoprotein Receptor-Related Protein-1
Cholesterol
Brain
Neurodegenerative Diseases
Cognition
Signal Transduction
Carrier Proteins
Protein Isoforms
Cell Membrane
Learning
Ligands
reelin receptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cell Biology

Cite this

Reelin, lipoprotein receptors and synaptic plasticity. / Herz, Joachim; Chen, Ying.

In: Nature Reviews Neuroscience, Vol. 7, No. 11, 11.2006, p. 850-859.

Research output: Contribution to journalArticle

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