TY - JOUR
T1 - Reelin, lipoprotein receptors and synaptic plasticity
AU - Herz, Joachim
AU - Chen, Ying
N1 - Funding Information:
The authors acknowledge support by grants from the National Institutes of Health.
PY - 2006/11
Y1 - 2006/11
N2 - Apolipoprotein E (APOE) is a cholesterol transport protein and an isoform-specific major risk factor for neurodegenerative diseases. The lipoprotein receptors that bind APOE have recently been recognized as pivotal components of the neuronal signalling machinery. The interaction between APOE receptors and one of their ligands, reelin, allows them to function directly as signal transduction receptors at the plasma membrane to control not only neuronal positioning during brain development, but also synaptic plasticity in the adult brain. Here, we review the molecular mechanisms through which APOE, cholesterol, reelin and APOE receptors control synaptic functions that are essential for cognition, learning, memory, behaviour and neuronal survival.
AB - Apolipoprotein E (APOE) is a cholesterol transport protein and an isoform-specific major risk factor for neurodegenerative diseases. The lipoprotein receptors that bind APOE have recently been recognized as pivotal components of the neuronal signalling machinery. The interaction between APOE receptors and one of their ligands, reelin, allows them to function directly as signal transduction receptors at the plasma membrane to control not only neuronal positioning during brain development, but also synaptic plasticity in the adult brain. Here, we review the molecular mechanisms through which APOE, cholesterol, reelin and APOE receptors control synaptic functions that are essential for cognition, learning, memory, behaviour and neuronal survival.
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U2 - 10.1038/nrn2009
DO - 10.1038/nrn2009
M3 - Review article
C2 - 17053810
AN - SCOPUS:33750333569
SN - 1471-003X
VL - 7
SP - 850
EP - 859
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 11
ER -