Regional differences in blood flow and oxygen consumption in resting muscle and their relationship during recovery from exhaustive exercise

Masaki Mizuno, Yuichi Kimura, Takashi Iwakawa, Keiichi Oda, Kenji Ishii, Kiichi Ishiwata, Yoshio Nakamura, Isao Muraoka

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

This investigation evaluated regional differences in blood flow and oxygen consumption and their relationship in exercised muscle during recovery from exhaustive exercise. Five healthy men performed exhaustive one-legged cycling exercise. Positron emission tomography was used to measure blood flow, oxygen uptake, and oxygen extraction in the quadriceps femoris muscle before and after exercise. Regions of interest included five areas of the muscle (two proximal, one central, and two distal), which were evenly spaced across the muscle. Before exercise, blood flow and oxygen consumption decreased significantly (P < 0.05) in the direction from the proximal to the distal portions; blood flow declined from 2.0 ± 0.5 to 1.4 ± 0.3 ml·100 g -1·min-1, and oxygen consumption decreased from 0.21 ± 0.04 to 0.17 ± 0.02 ml·100 g-1· min-1. In contrast, these gradients in blood flow and oxygen consumption diminished during recovery after exercise. Consequently, there was a positive relationship between changes in blood flow and oxygen consumption in an exercised muscle during recovery after exercise (r = 0.963, P < 0.01). These changes became larger in the direction from proximal to distal portions: blood flow increased from 2.9 ± 0.7 to 3.9 ± 0.8 and oxygen consumption from 1.4 ± 0.1 to 1.8 ± 0.4 times resting values. These results suggest that hemodynamic variables are heterogeneous within a muscle both at rest and during recovery from exercise and that there is a systematic difference in these variables in the direction from proximal to distal regions within the quadriceps femoris muscle.

Original languageEnglish (US)
Pages (from-to)2204-2210
Number of pages7
JournalJournal of Applied Physiology
Volume95
Issue number6
StatePublished - Dec 2003

Fingerprint

Oxygen Consumption
Exercise
Muscles
Quadriceps Muscle
Oxygen
Positron-Emission Tomography
Hemodynamics
Direction compound

Keywords

  • Heterogeneity
  • Positron emission tomography
  • Skeletal muscle

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Regional differences in blood flow and oxygen consumption in resting muscle and their relationship during recovery from exhaustive exercise. / Mizuno, Masaki; Kimura, Yuichi; Iwakawa, Takashi; Oda, Keiichi; Ishii, Kenji; Ishiwata, Kiichi; Nakamura, Yoshio; Muraoka, Isao.

In: Journal of Applied Physiology, Vol. 95, No. 6, 12.2003, p. 2204-2210.

Research output: Contribution to journalArticle

Mizuno, M, Kimura, Y, Iwakawa, T, Oda, K, Ishii, K, Ishiwata, K, Nakamura, Y & Muraoka, I 2003, 'Regional differences in blood flow and oxygen consumption in resting muscle and their relationship during recovery from exhaustive exercise', Journal of Applied Physiology, vol. 95, no. 6, pp. 2204-2210.
Mizuno, Masaki ; Kimura, Yuichi ; Iwakawa, Takashi ; Oda, Keiichi ; Ishii, Kenji ; Ishiwata, Kiichi ; Nakamura, Yoshio ; Muraoka, Isao. / Regional differences in blood flow and oxygen consumption in resting muscle and their relationship during recovery from exhaustive exercise. In: Journal of Applied Physiology. 2003 ; Vol. 95, No. 6. pp. 2204-2210.
@article{fe239fc19e5841b6b0ffbb3b39c18bf4,
title = "Regional differences in blood flow and oxygen consumption in resting muscle and their relationship during recovery from exhaustive exercise",
abstract = "This investigation evaluated regional differences in blood flow and oxygen consumption and their relationship in exercised muscle during recovery from exhaustive exercise. Five healthy men performed exhaustive one-legged cycling exercise. Positron emission tomography was used to measure blood flow, oxygen uptake, and oxygen extraction in the quadriceps femoris muscle before and after exercise. Regions of interest included five areas of the muscle (two proximal, one central, and two distal), which were evenly spaced across the muscle. Before exercise, blood flow and oxygen consumption decreased significantly (P < 0.05) in the direction from the proximal to the distal portions; blood flow declined from 2.0 ± 0.5 to 1.4 ± 0.3 ml·100 g -1·min-1, and oxygen consumption decreased from 0.21 ± 0.04 to 0.17 ± 0.02 ml·100 g-1· min-1. In contrast, these gradients in blood flow and oxygen consumption diminished during recovery after exercise. Consequently, there was a positive relationship between changes in blood flow and oxygen consumption in an exercised muscle during recovery after exercise (r = 0.963, P < 0.01). These changes became larger in the direction from proximal to distal portions: blood flow increased from 2.9 ± 0.7 to 3.9 ± 0.8 and oxygen consumption from 1.4 ± 0.1 to 1.8 ± 0.4 times resting values. These results suggest that hemodynamic variables are heterogeneous within a muscle both at rest and during recovery from exercise and that there is a systematic difference in these variables in the direction from proximal to distal regions within the quadriceps femoris muscle.",
keywords = "Heterogeneity, Positron emission tomography, Skeletal muscle",
author = "Masaki Mizuno and Yuichi Kimura and Takashi Iwakawa and Keiichi Oda and Kenji Ishii and Kiichi Ishiwata and Yoshio Nakamura and Isao Muraoka",
year = "2003",
month = "12",
language = "English (US)",
volume = "95",
pages = "2204--2210",
journal = "Journal of Applied Physiology",
issn = "0161-7567",
publisher = "American Physiological Society",
number = "6",

}

TY - JOUR

T1 - Regional differences in blood flow and oxygen consumption in resting muscle and their relationship during recovery from exhaustive exercise

AU - Mizuno, Masaki

AU - Kimura, Yuichi

AU - Iwakawa, Takashi

AU - Oda, Keiichi

AU - Ishii, Kenji

AU - Ishiwata, Kiichi

AU - Nakamura, Yoshio

AU - Muraoka, Isao

PY - 2003/12

Y1 - 2003/12

N2 - This investigation evaluated regional differences in blood flow and oxygen consumption and their relationship in exercised muscle during recovery from exhaustive exercise. Five healthy men performed exhaustive one-legged cycling exercise. Positron emission tomography was used to measure blood flow, oxygen uptake, and oxygen extraction in the quadriceps femoris muscle before and after exercise. Regions of interest included five areas of the muscle (two proximal, one central, and two distal), which were evenly spaced across the muscle. Before exercise, blood flow and oxygen consumption decreased significantly (P < 0.05) in the direction from the proximal to the distal portions; blood flow declined from 2.0 ± 0.5 to 1.4 ± 0.3 ml·100 g -1·min-1, and oxygen consumption decreased from 0.21 ± 0.04 to 0.17 ± 0.02 ml·100 g-1· min-1. In contrast, these gradients in blood flow and oxygen consumption diminished during recovery after exercise. Consequently, there was a positive relationship between changes in blood flow and oxygen consumption in an exercised muscle during recovery after exercise (r = 0.963, P < 0.01). These changes became larger in the direction from proximal to distal portions: blood flow increased from 2.9 ± 0.7 to 3.9 ± 0.8 and oxygen consumption from 1.4 ± 0.1 to 1.8 ± 0.4 times resting values. These results suggest that hemodynamic variables are heterogeneous within a muscle both at rest and during recovery from exercise and that there is a systematic difference in these variables in the direction from proximal to distal regions within the quadriceps femoris muscle.

AB - This investigation evaluated regional differences in blood flow and oxygen consumption and their relationship in exercised muscle during recovery from exhaustive exercise. Five healthy men performed exhaustive one-legged cycling exercise. Positron emission tomography was used to measure blood flow, oxygen uptake, and oxygen extraction in the quadriceps femoris muscle before and after exercise. Regions of interest included five areas of the muscle (two proximal, one central, and two distal), which were evenly spaced across the muscle. Before exercise, blood flow and oxygen consumption decreased significantly (P < 0.05) in the direction from the proximal to the distal portions; blood flow declined from 2.0 ± 0.5 to 1.4 ± 0.3 ml·100 g -1·min-1, and oxygen consumption decreased from 0.21 ± 0.04 to 0.17 ± 0.02 ml·100 g-1· min-1. In contrast, these gradients in blood flow and oxygen consumption diminished during recovery after exercise. Consequently, there was a positive relationship between changes in blood flow and oxygen consumption in an exercised muscle during recovery after exercise (r = 0.963, P < 0.01). These changes became larger in the direction from proximal to distal portions: blood flow increased from 2.9 ± 0.7 to 3.9 ± 0.8 and oxygen consumption from 1.4 ± 0.1 to 1.8 ± 0.4 times resting values. These results suggest that hemodynamic variables are heterogeneous within a muscle both at rest and during recovery from exercise and that there is a systematic difference in these variables in the direction from proximal to distal regions within the quadriceps femoris muscle.

KW - Heterogeneity

KW - Positron emission tomography

KW - Skeletal muscle

UR - http://www.scopus.com/inward/record.url?scp=0344276466&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344276466&partnerID=8YFLogxK

M3 - Article

C2 - 12871962

AN - SCOPUS:0344276466

VL - 95

SP - 2204

EP - 2210

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 0161-7567

IS - 6

ER -