Regional lung growth following pneumonectomy assessed by computed tomography

Priya Ravikumar, Cuneyt Yilmaz, D. Merrill Dane, Robert L. Johnson, Aaron S. Estrera, Connie C W Hsia

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

After pneumonectomy (PNX), mechanical strain on the remaining lung is greatly increased. To assess whether remaining lobes expand uniformly after left or right PNX (removing 42 and 58% of lung mass, respectively), we performed high-resolution computed tomography (CT) scans at 45 ml/kg above end-expiratory lung volume on adult male foxhounds after left or right PNX, which were compared with adult Sham controls. Air and tissue volumes were separately measured in each lobe. After left PNX, air and tissue volumes in the right upper and cardiac lobes increased ∼2.2-fold above and below the heart, whereas volumes in right middle and lower lobes did not change significantly. After right PNX, air and tissue volumes in the left upper and middle lobes increased 2.3- to 2.7-fold across the midline anterior to the heart, whereas the left lower lobe expanded ∼1.9-fold posterior to the heart. Regional changes in volume density of tissue post-PNX estimated by CT scan parallel postmortem estimates by morphometric analyses. Data indicate heterogeneous regional distribution of mechanical lung strain, which could influence the differential cellular compensatory response following right and left PNX.

Original languageEnglish (US)
Pages (from-to)1567-1574
Number of pages8
JournalJournal of applied physiology
Volume97
Issue number4
DOIs
StatePublished - Oct 1 2004

Keywords

  • Compensatory lung growth
  • Dog
  • High-resolution computed tomography scan
  • Lobar tissue volume
  • Lung resection
  • Mechanical lung strain

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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