Regulation of CDC14: Pathways and checkpoints of mitotic exit

Joshua Bembenek, Hongtao Yu

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Progression of the mitotic cell cycle is driven by fluctuations of the cyclin-dependent kinase (Cdk) activities. Entry into mitosis is promoted by the elevated activity of Cdk1 associated with B-type cyclins. Conversely, exit from mitosis requires the inactivation of Cdk1 and the dephosphorylation of at least a subset of Cdk1 substrates. The Cdc14 family of phosphatases antagonizes the action of Cdk1, and is thus a major player in controlling the mitotic exit. We review recent discoveries in several model systems that have shed light on the function of Cdc14 and propose a general framework within which Cdc14 plays conserved roles in regulating the exit from mitosis and cytokinesis.

Original languageEnglish (US)
Pages (from-to)d1276-d1288
JournalFrontiers in Bioscience
Volume8
StatePublished - Dec 1 2003

Keywords

  • Anaphase-Promoting Complex
  • Cdc14
  • Cdc20
  • Cdh1
  • Cell Cycle
  • Checkpoint
  • FEAR
  • MEN
  • Mitosis
  • Review
  • SIN
  • Ubiquitination

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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