Abstract
The results of the present investigation support the conclusion that low-density lipoprotein (LDL)-cholesterol facilitates androgen synthesis in human chorionic gonadotropin (hCG)-treated human fetal testicular tissue in vitro. Moreover, the number of LDL receptors and the rate of de novo synthesis of cholesterol are high during the period of active fetal testicular steroidogenesis and fall with advancing gestational age, suggestive of regulation by hCG.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 241-247 |
| Number of pages | 7 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 146 |
| Issue number | 3 |
| State | Published - Jun 1 1983 |
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ASJC Scopus subject areas
- Medicine(all)
- Obstetrics and Gynecology
Cite this
Regulation of human fetal testicular secretion of testosterone : Low-density lipoprotein-cholesterol and cholesterol synthesized de novo as steroid precursor. / Carr, Bruce R.; Parker, C. Richard; Ohashi, Masao; MacDonald, Paul C.; Simpson, Evan R.
In: American Journal of Obstetrics and Gynecology, Vol. 146, No. 3, 01.06.1983, p. 241-247.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of human fetal testicular secretion of testosterone
T2 - Low-density lipoprotein-cholesterol and cholesterol synthesized de novo as steroid precursor
AU - Carr, Bruce R.
AU - Parker, C. Richard
AU - Ohashi, Masao
AU - MacDonald, Paul C.
AU - Simpson, Evan R.
PY - 1983/6/1
Y1 - 1983/6/1
N2 - The results of the present investigation support the conclusion that low-density lipoprotein (LDL)-cholesterol facilitates androgen synthesis in human chorionic gonadotropin (hCG)-treated human fetal testicular tissue in vitro. Moreover, the number of LDL receptors and the rate of de novo synthesis of cholesterol are high during the period of active fetal testicular steroidogenesis and fall with advancing gestational age, suggestive of regulation by hCG.
AB - The results of the present investigation support the conclusion that low-density lipoprotein (LDL)-cholesterol facilitates androgen synthesis in human chorionic gonadotropin (hCG)-treated human fetal testicular tissue in vitro. Moreover, the number of LDL receptors and the rate of de novo synthesis of cholesterol are high during the period of active fetal testicular steroidogenesis and fall with advancing gestational age, suggestive of regulation by hCG.
UR - http://www.scopus.com/inward/record.url?scp=0020577278&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020577278&partnerID=8YFLogxK
M3 - Article
C2 - 6305195
AN - SCOPUS:0020577278
VL - 146
SP - 241
EP - 247
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 3
ER -