Regulation of human fetal testicular secretion of testosterone: Low-density lipoprotein-cholesterol and cholesterol synthesized de novo as steroid precursor

Bruce R. Carr; C. Richard Parker; Masao Ohashi; Paul C. MacDonald; Evan R. Simpson

doi:10.1016/0002-9378(83)90743-3

Regulation of human fetal testicular secretion of testosterone: Low-density lipoprotein-cholesterol and cholesterol synthesized de novo as steroid precursor

Bruce R. Carr, C. Richard Parker, Masao Ohashi, Paul C. MacDonald, Evan R. Simpson

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The results of the present investigation support the conclusion that low-density lipoprotein (LDL)-cholesterol facilitates androgen synthesis in human chorionic gonadotropin (hCG)-treated human fetal testicular tissue in vitro. Moreover, the number of LDL receptors and the rate of de novo synthesis of cholesterol are high during the period of active fetal testicular steroidogenesis and fall with advancing gestational age, suggestive of regulation by hCG.

Original language	English (US)
Pages (from-to)	241-247
Number of pages	7
Journal	American journal of obstetrics and gynecology
Volume	146
Issue number	3
DOIs	https://doi.org/10.1016/0002-9378(83)90743-3
State	Published - Jun 1 1983

ASJC Scopus subject areas

Obstetrics and Gynecology

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Regulation of human fetal testicular secretion of testosterone : Low-density lipoprotein-cholesterol and cholesterol synthesized de novo as steroid precursor. / Carr, Bruce R.; Parker, C. Richard; Ohashi, Masao; MacDonald, Paul C.; Simpson, Evan R.

In: American journal of obstetrics and gynecology, Vol. 146, No. 3, 01.06.1983, p. 241-247.

Research output: Contribution to journal › Article › peer-review

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