Regulation of human fetal testicular secretion of testosterone: Low-density lipoprotein-cholesterol and cholesterol synthesized de novo as steroid precursor

Bruce R. Carr, C. Richard Parker, Masao Ohashi, Paul C. MacDonald, Evan R. Simpson

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The results of the present investigation support the conclusion that low-density lipoprotein (LDL)-cholesterol facilitates androgen synthesis in human chorionic gonadotropin (hCG)-treated human fetal testicular tissue in vitro. Moreover, the number of LDL receptors and the rate of de novo synthesis of cholesterol are high during the period of active fetal testicular steroidogenesis and fall with advancing gestational age, suggestive of regulation by hCG.

Original languageEnglish (US)
Pages (from-to)241-247
Number of pages7
JournalAmerican journal of obstetrics and gynecology
Volume146
Issue number3
DOIs
StatePublished - Jun 1 1983

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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