Regulation of human hair growth by steroid hormones. II. Androstenedione metabolism in isolated hairs

H. U. Schweikert, J. D. Wilson

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

[1,2 3H] Androstenedione metabolism has been measured under standardized conditions in growing and resting hair roots from varying anatomical sites from 5 women and 12 men, 6 of whom had male pattern baldness. 5α Reduced and 17β hydroxy steroids were the major metabolites of androstenedione. Hairs from all body regions have the capacity to transform androstenedione into testosterone, but the rate of the reduction of 17 ketosteroids is less than the rate of oxidation so that the 17 keto rather than 17β hydroxysteroids tend to accumulate in the cell. Since the 5α reduction is irreversible and conditions favor the formation of 17 ketosteroids, androstenedione is the principal intracellular androgen in the hair root.

Original languageEnglish (US)
Pages (from-to)1012-1019
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume39
Issue number6
StatePublished - 1974

Fingerprint

Steroid hormones
Androstenedione
Metabolism
Hair
Growth Hormone
Steroids
17-Ketosteroids
Hydroxysteroids
Body Regions
Alopecia
Metabolites
Androgens
Testosterone
Oxidation

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Regulation of human hair growth by steroid hormones. II. Androstenedione metabolism in isolated hairs. / Schweikert, H. U.; Wilson, J. D.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 39, No. 6, 1974, p. 1012-1019.

Research output: Contribution to journalArticle

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