Regulation of human hair growth by steroid hormones. II. androstenedione metabolism in isolated hairs

H. U. Schweikert, J. D. Wilson

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Andrqstenedione-1, 2-3H metabolism has been measured under standardized conditions in growing and resting hair roots from varying anatomical sites from 5 women and 12 men, 6 of whom had male pattern baldness. 5α-Reduced and 17β-hydroxysteroids were the major metabolites of androstenedione. Hairs from all body regions have the capacity to transform androstenedione into testosterone but the rate of the reduction of 17-ketosteroids is less than the rate of oxidation so that the 17-keto rather than 17β-hydroxysteroids tend to accumulate in the cell. Since the 5α-reduction is irreversible and conditions favor the formation of 17-ketosteroids, androstanedione is the principal intracellular androgen in the hair root.

Original languageEnglish (US)
Pages (from-to)1012-1019
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume39
Issue number6
DOIs
StatePublished - Dec 1974

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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