Regulation of mammalian transcription and splicing by Nuclear RNAi

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

RNA interference (RNAi) is well known as a mechanism for controlling mammalian mRNA translation in the cytoplasm, but what would be the consequences if it also functions in cell nuclei? Although RNAi has also been found in nuclei of plants, yeast, and other organisms, there has been relatively little progress towards understanding the potential involvement of mammalian RNAi factors in nuclear processes including transcription and splicing. This review summarizes evidence for mammalian RNAi factors in cell nuclei and mechanisms that might contribute to the control of gene expression. When RNAi factors bind small RNAs, they form ribonucleoprotein complexes that can be selective for target sequences within different classes of nuclear RNA substrates. The versatility of nuclear RNAi may supply a previously underappreciated layer of regulation to transcription, splicing, and other nuclear processes.

Original languageEnglish (US)
Pages (from-to)524-537
Number of pages14
JournalNucleic Acids Research
Volume44
Issue number2
DOIs
StatePublished - Jan 29 2016

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Nuclear RNA
RNA Interference
Cell Nucleus
Ribonucleoproteins
Protein Biosynthesis
Cytoplasm
Yeasts
RNA
Gene Expression

ASJC Scopus subject areas

  • Genetics

Cite this

Regulation of mammalian transcription and splicing by Nuclear RNAi. / Kalantari, Roya; Chiang, Cheng Ming; Corey, David R.

In: Nucleic Acids Research, Vol. 44, No. 2, 29.01.2016, p. 524-537.

Research output: Contribution to journalArticle

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