Regulation of plasma cholesterol by lipoprotein receptors

Research output: Contribution to journalReview article

575 Scopus citations

Abstract

The lipoprotein transport system holds the key to understanding the mechanisms by which genes, diet, and hormones interact to regulate the plasma cholesterol level in man. Crucial components of this system are lipoprotein receptors in the liver and extrahepatic tissues that mediate the uptake and degradation of cholesterol-carrying lipoproteins. The number of lipoprotein receptors, and hence the efficiency of disposal of plasma cholesterol, can be increased by cholesterol-lowering drugs. Regulation of lipoprotein receptors can be exploited pharmacologically in the therapy of hypercholesterolemia and atherosclerosis in man.

Original languageEnglish (US)
Pages (from-to)628-635
Number of pages8
JournalScience
Volume212
Issue number4495
DOIs
StatePublished - Jan 1 1981

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