Regulation of plasma cholesterol by lipoprotein receptors

Research output: Contribution to journalArticle

573 Citations (Scopus)

Abstract

The lipoprotein transport system holds the key to understanding the mechanisms by which genes, diet, and hormones interact to regulate the plasma cholesterol level in man. Crucial components of this system are lipoprotein receptors in the liver and extrahepatic tissues that mediate the uptake and degradation of cholesterol-carrying lipoproteins. The number of lipoprotein receptors, and hence the efficiency of disposal of plasma cholesterol, can be increased by cholesterol-lowering drugs. Regulation of lipoprotein receptors can be exploited pharmacologically in the therapy of hypercholesterolemia and atherosclerosis in man.

Original languageEnglish (US)
Pages (from-to)628-635
Number of pages8
JournalScience
Volume212
Issue number4495
StatePublished - 1981

Fingerprint

Lipoprotein Receptors
Cholesterol
Hypercholesterolemia
Lipoproteins
Atherosclerosis
Hormones
Diet
Liver
Pharmaceutical Preparations
Genes
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Regulation of plasma cholesterol by lipoprotein receptors. / Brown, Michael S.; Kovanen, Petri T.; Goldstein, Joseph L.

In: Science, Vol. 212, No. 4495, 1981, p. 628-635.

Research output: Contribution to journalArticle

Brown, Michael S. ; Kovanen, Petri T. ; Goldstein, Joseph L. / Regulation of plasma cholesterol by lipoprotein receptors. In: Science. 1981 ; Vol. 212, No. 4495. pp. 628-635.
@article{1ab89dd0b5a94ab89e629691f3125231,
title = "Regulation of plasma cholesterol by lipoprotein receptors",
abstract = "The lipoprotein transport system holds the key to understanding the mechanisms by which genes, diet, and hormones interact to regulate the plasma cholesterol level in man. Crucial components of this system are lipoprotein receptors in the liver and extrahepatic tissues that mediate the uptake and degradation of cholesterol-carrying lipoproteins. The number of lipoprotein receptors, and hence the efficiency of disposal of plasma cholesterol, can be increased by cholesterol-lowering drugs. Regulation of lipoprotein receptors can be exploited pharmacologically in the therapy of hypercholesterolemia and atherosclerosis in man.",
author = "Brown, {Michael S.} and Kovanen, {Petri T.} and Goldstein, {Joseph L.}",
year = "1981",
language = "English (US)",
volume = "212",
pages = "628--635",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4495",

}

TY - JOUR

T1 - Regulation of plasma cholesterol by lipoprotein receptors

AU - Brown, Michael S.

AU - Kovanen, Petri T.

AU - Goldstein, Joseph L.

PY - 1981

Y1 - 1981

N2 - The lipoprotein transport system holds the key to understanding the mechanisms by which genes, diet, and hormones interact to regulate the plasma cholesterol level in man. Crucial components of this system are lipoprotein receptors in the liver and extrahepatic tissues that mediate the uptake and degradation of cholesterol-carrying lipoproteins. The number of lipoprotein receptors, and hence the efficiency of disposal of plasma cholesterol, can be increased by cholesterol-lowering drugs. Regulation of lipoprotein receptors can be exploited pharmacologically in the therapy of hypercholesterolemia and atherosclerosis in man.

AB - The lipoprotein transport system holds the key to understanding the mechanisms by which genes, diet, and hormones interact to regulate the plasma cholesterol level in man. Crucial components of this system are lipoprotein receptors in the liver and extrahepatic tissues that mediate the uptake and degradation of cholesterol-carrying lipoproteins. The number of lipoprotein receptors, and hence the efficiency of disposal of plasma cholesterol, can be increased by cholesterol-lowering drugs. Regulation of lipoprotein receptors can be exploited pharmacologically in the therapy of hypercholesterolemia and atherosclerosis in man.

UR - http://www.scopus.com/inward/record.url?scp=0019473234&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019473234&partnerID=8YFLogxK

M3 - Article

C2 - 6261329

AN - SCOPUS:0019473234

VL - 212

SP - 628

EP - 635

JO - Science

JF - Science

SN - 0036-8075

IS - 4495

ER -