Regulation of pulmonary surfactant protein synthesis in fetal lung: A major role of glucocorticoids and cyclic AMP

Carole R. Mendelson, Vijayakumar Boggaram

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Augmented synthesis of the lipoprotein, pulmonary surfactant, is initiated in fetal lung toward the end of-gestation. Inadequate surfactant synthesis by the lungs of premature infants can result in respiratory distress syndrome, the leading cause of neonatal morbidity and mortality in developed countries. The surfactant-associated proteins act with surfactant glycerophospholipids to reduce alveolar surface tension, and mediate the reutilization of secreted surfactant components by type II cells. Genes encoding the surfactant proteins SP-A, SP-B, and SP-C have been isolated and characterized. Recent findings suggest that surfactant protein gene expression in fetal lung is under multifactortal control and is regulated by glucocorticoids, cAMP, growth factors, and insulin.

Original languageEnglish (US)
Pages (from-to)20-25
Number of pages6
JournalTrends in Endocrinology and Metabolism
Volume1
Issue number1
DOIs
StatePublished - 1989

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Pulmonary Surfactant-Associated Proteins
Surface-Active Agents
Cyclic AMP
Glucocorticoids
Lung
Pulmonary Surfactant-Associated Protein A
Glycerophospholipids
Pulmonary Surfactants
Surface Tension
Infant Mortality
Cellular Structures
Developed Countries
Premature Infants
Lipoproteins
Intercellular Signaling Peptides and Proteins
Proteins
Insulin
Morbidity
Gene Expression
Pregnancy

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Regulation of pulmonary surfactant protein synthesis in fetal lung : A major role of glucocorticoids and cyclic AMP. / Mendelson, Carole R.; Boggaram, Vijayakumar.

In: Trends in Endocrinology and Metabolism, Vol. 1, No. 1, 1989, p. 20-25.

Research output: Contribution to journalArticle

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