Regulation of pulmonary surfactant protein synthesis in fetal lung: A major role of glucocorticoids and cyclic AMP

Carole R. Mendelson, Vijayakumar Boggaram

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Augmented synthesis of the lipoprotein, pulmonary surfactant, is initiated in fetal lung toward the end of-gestation. Inadequate surfactant synthesis by the lungs of premature infants can result in respiratory distress syndrome, the leading cause of neonatal morbidity and mortality in developed countries. The surfactant-associated proteins act with surfactant glycerophospholipids to reduce alveolar surface tension, and mediate the reutilization of secreted surfactant components by type II cells. Genes encoding the surfactant proteins SP-A, SP-B, and SP-C have been isolated and characterized. Recent findings suggest that surfactant protein gene expression in fetal lung is under multifactortal control and is regulated by glucocorticoids, cAMP, growth factors, and insulin.

Original languageEnglish (US)
Pages (from-to)20-25
Number of pages6
JournalTrends in Endocrinology and Metabolism
Volume1
Issue number1
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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