TY - JOUR
T1 - Regulation of rat placental phosphorylase
AU - Ross, Elliott
AU - Walsh, Donal
PY - 1972/5/16
Y1 - 1972/5/16
N2 - Glycogen phosphorylase (α-1,4-glucan: orthophosphate glucosyltransferase, EC 2.4.1.1) from rat placenta has been shown to exist in AMP-dependent and -independent forms that are designated phosphorylase b and a, respectively. Phosphorylase b exhibits a Ka of 1.5·10-4 M for AMP and is stimulated by 0.7 M Na2SO4 in the presence or absence of the nucleotide; in contrast, phosphorylase a is inhibited by Na2SO4. Placental extracts contain a phosphorylase kinase, a phosphorylase phosphatase and a cyclic AMP-dependent protein kinase which are presumed to be associated with the control of glycogenolysis in this tissue.
AB - Glycogen phosphorylase (α-1,4-glucan: orthophosphate glucosyltransferase, EC 2.4.1.1) from rat placenta has been shown to exist in AMP-dependent and -independent forms that are designated phosphorylase b and a, respectively. Phosphorylase b exhibits a Ka of 1.5·10-4 M for AMP and is stimulated by 0.7 M Na2SO4 in the presence or absence of the nucleotide; in contrast, phosphorylase a is inhibited by Na2SO4. Placental extracts contain a phosphorylase kinase, a phosphorylase phosphatase and a cyclic AMP-dependent protein kinase which are presumed to be associated with the control of glycogenolysis in this tissue.
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U2 - 10.1016/0304-4165(72)90012-8
DO - 10.1016/0304-4165(72)90012-8
M3 - Article
C2 - 4337493
AN - SCOPUS:0015512373
SN - 0304-4165
VL - 264
SP - 490
EP - 496
JO - BBA - General Subjects
JF - BBA - General Subjects
IS - 3
ER -